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CHONDROITIN SULFATE AND GLUCOSAMINE SULFATE AS PROTECTIVE AND ANTI-INFLAMMATORY AGENTS IN THE ULCERATIVE COLITIS DSS MODEL IN RATS.
Arq Gastroenterol
December 2024
Instituto de Ciências Biológicas da Universidade Federal de Juiz de Fora, Laboratório de Análises de Glicoconjugados, Departamento de Bioquímica, Juiz de Fora, MG, Brasil.
Chondroitin sulfate (CS) and glucosamine (GlcN) are indicated for the treatment of some inflammatory diseases, such as osteoarthritis, mainly because of the anti-inflammatory effects in reducing metalloproteinases activities (MMP), and other inflammatory mediators. Herein, we reported the structure of the CS, the anti-inflammatory and protective effects of the CS, and GlcN administration in ulcerative colitis model induced by dextran sulfate sodium (DSS) in rats. Experimental data indicated that CS disaccharide composition is very similar to the C4S standard, with modal molecular weight at 30.
View Article and Find Full Text PDFCausality of genetically determined glucosamine supplementation on cognition and sarcopenia: a Mendelian randomization study.
Front Endocrinol (Lausanne)
January 2025
Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.
Background: Evidence indicates a negative link between glucosamine and age-related cognitive decline and sarcopenia. However, the causal relationship remains uncertain. This study aims to verify whether glucosamine is causally associated with cognitive function and sarcopenia.
View Article and Find Full Text PDFO-GlcNAcylation dictates pyroptosis.
Front Immunol
January 2025
Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.
Article Synopsis
- O-GlcNAcylation is a modification that adds a sugar molecule, N-acetylglucosamine, to specific amino acids, influencing signaling pathways important for pyroptosis, a form of cell death.
- Enhancing O-GlcNAcylation of the protein GSDMD is suggested as a key strategy for improving blood flow issues in sepsis, while GSDME's role in macrophage pyroptosis is linked to high glucose levels in periodontitis.
- The review discusses O-GlcNAcylation's impact on the NLRP3 inflammasome and other regulators, highlighting its potential as a therapeutic target for diseases like sepsis and osteoarthritis by managing inflammation.
[Chondroprotective therapy and adjuvant support for patients with chronic lower back pain].
Zh Nevrol Psikhiatr Im S S Korsakova
December 2024
International University of Restorative Medicine, Moscow, Russia.
The trend of an annual increase in the detection of new cases of osteoarthritis (OA) and an increase in the number of patients with chronic lower back pain (LBP) calls for the search for new drugs and pharmaconutraceuticals with anti-inflammatory and chondroprotective properties. In 2019, approaches to the treatment of pain in OA significantly changed. In international and Russian clinical guidelines (CG), pharmaconutraceutical chondroitin sulfate (CS) and glucosamine sulfate (GS) are recommended for OA of different localization as a basic therapy.
View Article and Find Full Text PDF[Mechanism of Astragali Radix in treatment of knee osteoarthritis based on GLP-1/GLP-1R axis].
Zhongguo Zhong Yao Za Zhi
November 2024
College of Basic Medical Sciences, Shanxi University of Chinese Medicine Jinzhong 030600, China.
This study aims to observe the effects of different doses of Astragali Radix on the expression of glucagon(GLP-1) in se-rum and glucagon receptor(GLP-1R) in cartilage tissue in rats with knee osteoarthritis(KOA), explore the effect of Astragali Radix on the inflammation and apoptosis of KOA by regulating GLP-1/GLP-1R signaling axis, and investigate the mechanism of its action in alleviating KOA. Forty-eight male SD rats were randomly divided into six groups: blank group, model group, low-, medium-, and high-dose Astragali Radix groups(3.125, 6.
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