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Severe sepsis-associated acute kidney injury and outcomes: a longitudinal cohort study.
Intern Med J
January 2025
School of Medicine, Flinders University, Adelaide, South Australia, Australia.
Background: Sepsis-associated acute kidney injury (SA-AKI) is common among patients admitted to the intensive care unit (ICU) with sepsis.
Aims: This study aimed to demonstrate an association between an episode of SA-AKI and progression to dialysis dependence, with a view to identifying a cohort who may be suitable for intensive nephrology follow-up.
Methods: Design: Retrospective data-linkage cohort study.
Complex portal 2025: predicted human complexes and enhanced visualisation tools for the comparison of orthologous and paralogous complexes.
Nucleic Acids Res
January 2025
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
The Complex Portal (www.ebi.ac.
View Article and Find Full Text PDFThe modern synthesis and "Progress" in evolution: a view from the journal literature.
Hist Philos Life Sci
November 2024
Institut supérieur de philosophie, Université catholique de Louvain, Place du Cardinal Mercier 14, 1348, Louvain-La-Neuve, Belgium.
The concept of "progress" in evolutionary theory and its relationship to a putative notion of "Progress" in a global, normatively loaded sense of "change for the better" have been the subject of debate since Darwin admonished himself in a marginal note to avoid using the terms 'higher' and 'lower.' While an increase in some kind of complexity in the natural world might seem self-evident, efforts to explicate this trend meet notorious philosophical difficulties. Numerous historians pin the Modern Synthesis as a pivotal moment in this history; Michael Ruse even provocatively hypothesizes that Ernst Mayr and other "architects" of the Synthesis worked actively to eliminate Progress from evolutionary biology's scientific purview.
View Article and Find Full Text PDFA scenario for an evolutionary selection of ageing.
Elife
November 2024
Université Paris Cité, Institut Jacques Monod, Paris, France.
Signs of ageing become apparent only late in life, after organismal development is finalized. Ageing, most notably, decreases an individual's fitness. As such, it is most commonly perceived as a non-adaptive force of evolution and considered a by-product of natural selection.
View Article and Find Full Text PDFNEARER SCAN (LENO BESIK) evaluation of a task-sharing echocardiographic active case finding programme for rheumatic heart disease in Australia and Timor-Leste: protocol for a hybrid type II effectiveness-implementation study.
BMJ Open
October 2024
Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
Introduction: Rheumatic heart disease (RHD) is underdiagnosed globally resulting in missed treatment opportunities and adverse clinical outcomes. We describe the protocol for a study which aims to co-design, implement and conduct an evaluation of a task-sharing approach to echocardiographic active case finding for early detection and management of RHD in high-risk settings in Australia and Timor-Leste.
Methods And Analysis: Echocardiograms will be obtained by trained local staff using hand-held echocardiographic devices employing the 'Single Parasternal Long Axis view with a Sweep of the Heart' (SPLASH) technique and interpreted by experts remote from the site of acquisition.
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