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Optimized genetic tools for neuroanatomical and functional mapping of the Aedes aegypti olfactory system.
G3 (Bethesda)
January 2025
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
The mosquito Aedes aegypti is an emerging model insect for invertebrate neurobiology. We detail the application of a dual transgenesis marker system that reports the nature of transgene integration with circular donor template for CRISPR-Cas9-mediated homology-directed repair at target mosquito chemoreceptor genes. Employing this approach, we demonstrate the establishment of cell-type-specific T2A-QF2 driver lines for the A.
View Article and Find Full Text PDFCorrelations between the blink reflex and magnetic resonance imaging in patients with trigeminal neuralgia.
Acta Neurol Belg
January 2025
Department of Radiology, Health Sciences University Gulhane Faculty of Medicine, Ankara, Turkey.
Background: Trigeminal neuralgia is a disease characterized by severe facial pain that significantly reduces patients quality of life. Trigeminal neuralgia is subcategorized as idiopathic, classic or secondary. Magnetic resonance imaging is the basis for classification, but neurophysiological tests are also used.
View Article and Find Full Text PDFReevaluating gender-affirming care: biological foundations, ethical dilemmas, and the complexities of gender dysphoria.
J Sex Marital Ther
January 2025
Department of Interdisciplinary Studies, University of South Florida, Tampa, FL, USA.
This paper critically examines the scientific and ethical underpinnings of gender-affirming care, particularly for minors. While major medical organizations endorse such interventions as medically necessary, the evidence supporting their long-term safety and efficacy remains limited. Research into hormonal, neuroanatomic, and genetic influences reveals a strong biological basis for gender identity, challenging social constructionist arguments.
View Article and Find Full Text PDFNeuroanatomical prediction of individual anxiety problems level using machine learning models: A population-based cohort study of young adults.
Neurobiol Stress
January 2025
Department of Neurosurgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Anxiety, a mental state in healthy individuals, is characterized by apprehension of potential future threats. Though the neurobiological basis of anxiety has been investigated widely in the clinical populations, the underly mechanism of neuroanatomical correlates with anxiety level in healthy young adults is still unclear. In this study, 1080 young adults were enrolled from the Human Connectome Project Young Adult dataset, and machine learning-based elastic net regression models with cross validation, together with linear mix effects (LME) models were adopted to investigate whether the neuroanatomical profiles of structural magnetic resonance imaging indicators associated with anxiety level in healthy young adults.
View Article and Find Full Text PDFPostoperative delirium is the most common postsurgical complication in older adults and is associated with an increased risk of long-term cognitive decline and Alzheimer's disease (AD) and related dementias (ADRD). However, the neurological basis of this increased risk- whether postoperative delirium unmasks latent preoperative pathology or leads to AD-relevant pathology after perioperative brain injury-remains unclear. Recent advancements in neuroimaging techniques now enable the detection of subtle brain features or damage that may underlie clinical symptoms.
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