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Avoiding prostate bed radiation for the PSMA-PET detected nodal recurrence patient post prostatectomy.
Clin Transl Radiat Oncol
January 2025
Northern Sydney Cancer Centre, Radiation Oncology Unit, Royal North Shore Hospital, St Leonards, Sydney, NSW, Australia.
Background: Nodal only recurrence post radical prostatectomy (RP) is increasingly recognised in the PSMA scan era. Management is controversial with a curative approach usually incorporating prostate bed and nodal irradiation (PB + NRT) in combination with long-term hormonal therapy. It is unknown whether omitting prostate-bed irradiation (PBRT) is safe in a subgroup of these patients.
View Article and Find Full Text PDFTransient CAR T cells with specificity to oncofetal glycosaminoglycans in solid tumors.
EMBO Mol Med
November 2024
Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Glycosaminoglycans are often deprioritized as targets for synthetic immunotherapy due to the complexity of glyco-epitopes and limited options for obtaining specific subtype binding. Solid tumors express proteoglycans that are modified with oncofetal chondroitin sulfate (CS), a modification normally restricted to the placenta. Here, we report the design and functionality of transient chimeric antigen receptor (CAR) T cells with selectivity to oncofetal CS.
View Article and Find Full Text PDFSemen uric acid crystals in azoospermia linked to Sertoli cell‑only syndrome: A rare case report.
Exp Ther Med
October 2024
Scientific Affairs Department, Smart Health Tower, Sulaymaniyah, Kurdistan 46001, Iraq.
The occurrence of crystals in semen is rare, with spermine phosphate crystals being the only type commonly described. Uric acid crystal formation is significantly influenced by pH levels. The present study reported a rare case of uric acid crystals in the semen of a patient with azoospermia associated with Sertoli cell-only syndrome (SCOS).
View Article and Find Full Text PDFEmerging cancer disease burden in a rural sub-Saharan African population: northeast Nigeria in focus.
Front Oncol
July 2024
Department of Obstetrics and Gynaecology, Federal University of Health Sciences Azare, Azare, Bauchi, Nigeria.
Introduction: Sub-Saharan Africa (SSA) is plagued by myriads of diseases, mostly infectious; but cancer disease burden is rising among non-communicable diseases. Nigeria has a high burden of cancer, however its remote underserved culturally-conserved populations have been understudied, a gap this study sought to fill.
Methods: This was a cross-sectional multi-institutional descriptive study of histologically diagnosed cancers over a four-year period (January 2019-December 2022) archived in the Departments of Pathology and Cancer Registries of six tertiary hospitals in the northeast of Nigeria.
Aggressive Prostate Cancer After a 14-Year Gonadotropin Therapy: A Case Report.
Cureus
June 2024
Department of Urology, Osaka Central Hospital, Osaka, JPN.
A 40-year-old man with a four-year history of infertility was referred to our department. The semen analysis revealed low motility, and the blood test showed low luteinizing hormone levels. Gonadotropin therapy was initiated upon the diagnosis of hypogonadotropic hypogonadism.
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