AI Article Synopsis
- The article discusses a case of small cell undifferentiated carcinoma originating in the submandibular gland, characterized by anaplastic cells that resemble lymphocytes.
- Immunohistochemical analysis showed positive reactions to various markers, indicating the tumor's complex nature.
- The case suggests that these carcinomas may originate from multipotential ductal stem cells and tend to be less aggressive in the salivary glands compared to primary tumors found in the lungs.
Article Abstract
This article reports the clinical, histopathologic, and immunohistochemical findings in a case of small cell undifferentiated carcinoma of the submandibular gland. The tumor was composed of anaplastic cells slightly larger than lymphocytes without ductal differentiation. On immunohistochemical analysis, the tumor contained cells that reacted positively with antibodies to cytokeratin, neuron-specific enolase, synaptophysin, and chromogranin. The present case supports the hypothesis that small cell undifferentiated carcinomas of the salivary glands arise from presumed multipotential ductal stem cells. When this tumor entity is located on the salivary glands, it appears to behave less aggressively than when it is a primary tumor of the bronchial tree.
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| http://dx.doi.org/10.1177/000348940411300113 | DOI Listing |
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