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Epigenetic Mechanisms in Osteoporosis: Exploring the Power of mA RNA Modification.
J Cell Mol Med
January 2025
Academy of Traditional Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou, China.
Osteoporosis, recognised as a metabolic disorder, has emerged as a significant burden on global health. Although available treatments have made considerable advancements, they remain inadequately addressed. In recent years, the role of epigenetic mechanisms in skeletal disorders has garnered substantial attention, particularly concerning mA RNA modification.
View Article and Find Full Text PDFBilateral Pediatric Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD) Optic Neuritis: A Case Report.
Cureus
November 2024
Ophthalmology, International Islamic University Malaysia, Kuantan, MYS.
Article Synopsis
- Optic neuritis (ON) is an acquired disorder of the optic nerve linked with demyelinating conditions and can present differently in children compared to adults.
- The main concern for healthcare providers is the potential development of multiple sclerosis (MS) in patients with ON, which has led to a greater emphasis on distinguishing between MS and other demyelinating disorders like NMOSD and MOGAD.
- The paper discusses a case of a child with severe MOGAD ON, detailing the clinical features, investigations, and treatment that resulted in complete visual recovery.
A scoping review of circulating peptides assessments in anorexia nervosa: Uncovering diversity and nuanced findings.
J Proteomics
February 2025
TAPE Research Group, Jean Monnet University, Lyon University, Saint-Etienne, France; Endocrinology Department, University Hospital of Saint-Etienne, Saint-Etienne, France; Eating Disorder Reference Center, University hospital of Saint-Etienne, Saint-Etienne, France.
Understanding biological mechanisms underlying anorexia nervosa (AN) is necessary to develop care strategies. Despite many articles dedicated to peptides assessment in AN, there is no systematic review. A scoping review of circulating peptides published in relation to AN, comparing their results with those of controls, was conducted.
View Article and Find Full Text PDFIs the Swallow Tail Sign a Useful Imaging Biomarker in Clinical Neurology? A Systematic Review.
Mov Disord Clin Pract
December 2024
1st Department of Neurology, University Hospital AHEPA, Faculty of Medicine Aristotle University of Thessaloniki, Thessaloniki, Greece.
Background: Loss of dorsolateral nigral hyperintensity (DNH) in iron-sensitive sequences of Magnetic Resonance Imaging (MRI), also described as "swallow tail sign" (STS) loss, has shown promising diagnostic value in Parkinson's Disease (PD) and Atypical Parkinsonian Syndromes (APS).
Objective: To conduct a bibliometric analysis on substantia nigra MRI and a systematic review on the clinical utility of STS visual assessment on Susceptibility-Weighted Imaging in various clinical entities.
Methods: VOSviewer's keyword co-occurrence network was employed using Web of Science (WOS).
Glutamic acid decarboxylase antibody-spectrum disorders and type 1 diabetes mellitus in a patient following allogenic hematopoietic cell transplantation with review of literature.
Endocr J
December 2024
Department of Epilepsy, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka 420-8688, Japan.
Article Synopsis
- * The presence of anti-GAD antibodies is linked to type 1 diabetes and various neurological disorders collectively referred to as GAD antibody-spectrum disorders (GAD-SD).
- * A case study of a 17-year-old male who developed GAD-SD and type 1 diabetes after a stem cell transplant is presented, showing symptoms like memory issues and abnormal brain scans, leading to treatment with steroids and insulin.
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