The essential oil and the aqueous, hexane and methanolic fractions from Hyptis ovalifolia leaves were evaluated for their antifungal activity in vitro against 60 strains of dermatophytes: 10 strains of Microsporum canis, 10 of M. gypseum, 20 of Trichophyton rubrum and 20 of T. mentagrophytes. The extracts inhibited growth of the dermatophytes tested at different concentrations. The most biologically active was the essential oil from the leaves which inhibited 57 isolates (95%) at a concentration of 500 g/ml.
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http://dx.doi.org/10.1590/s0074-02762003000700018 | DOI Listing |
Antimicrob Agents Chemother
November 2018
Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil
Paracoccidioidomycosis (PCM) is the cause of many deaths from systemic mycoses. The etiological agents of PCM belong to the genus, which is restricted to Latin America. The infection is acquired through the inhalation of conidia that primarily lodge in the lungs and may disseminate to other organs and tissues.
View Article and Find Full Text PDFPLoS Negl Trop Dis
January 2016
Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.
Paracoccidioides spp., a dimorphic pathogenic fungus, is the etiologic agent of paracoccidioidomycosis (PCM). PCM is an endemic disease that affects at least 10 million people in Latin America, causing severe public health problems.
View Article and Find Full Text PDFNat Prod Commun
November 2011
Department of Chemistry, University of the West Indies, Mona, Kingston 7, Jamaica.
Several species belonging to the Hyptis (Lamiaceae) genus represent an important source of bioactive constituents, which are reputed for their wide range of antimicrobial, anticancer and insecticidal activities. The volatile oils obtained from various parts of the Hyptis plants were found to be primarily composed of mono- and sesquiterpenes. Significant differences were observed in the percentage compositions of the major components, which allowed for differentiation among the species.
View Article and Find Full Text PDFMem Inst Oswaldo Cruz
October 2003
Laboratório de Micologia, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, GO, Brasil.
The essential oil and the aqueous, hexane and methanolic fractions from Hyptis ovalifolia leaves were evaluated for their antifungal activity in vitro against 60 strains of dermatophytes: 10 strains of Microsporum canis, 10 of M. gypseum, 20 of Trichophyton rubrum and 20 of T. mentagrophytes.
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