AI Article Synopsis
- Plumbagin, a naphthoquinone from the roots of Plumbago scandens, was studied for its antimicrobial properties.
- The plant, found in Rio de Janeiro, Brazil, is used in traditional medicine for various ailments.
- The findings indicated that plumbagin effectively inhibits the growth of Staphylococcus aureus and Candida albicans at low concentrations, suggesting its potential as an antimicrobial agent.
Article Abstract
Plumbagin is a naturally occurring naphthoquinone isolated from roots of Plumbago scandens. The plant was collected at the Campus of Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. P. scandens is used as a traditional medicine for the treatment of several diseases. The antimicrobial activity of plumbagin was evaluated using the macrodilution method. The compound exhibited relatively specific activity against bacteria and yeast. The minimum inhibitory concentration test showed the growth inhibiton of Staphylococcus aureus at a concentration of 1.56 g/ml and of Candida albicans at a concentration of 0.78 g/ml. These results suggest the naphthoquinone plumbagin as a promising antimicrobial agent.
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| http://dx.doi.org/10.1590/s0074-02762003000700017 | DOI Listing |
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