AI Article Synopsis
- The study explored how different types of radiographic contrast media (RCM) affect granulocyte adhesion during coronary angiography.
- It involved 37 patients and compared the effects of ionic versus non-ionic RCM on granulocyte adhesion molecules both in vivo and in vitro.
- The results showed that non-ionic RCM increased adhesion molecule expression in vivo, while ionic RCM had the opposite effect in vitro, highlighting the need to consider RCM type when analyzing leukocyte function in clinical settings.
Article Abstract
Background: Many papers have focused on the importance of granulocytes in the process of reperfusion and ischemia. Most of the clinical studies measured several parameters of this process during and after coronary angiography, without taking into account the effect of the radiographic contrast media (RCM) used during this procedure.
Materials And Methods: We performed a randomized patient study (n = 37) to evaluate the effect of ionic and non-ionic RCM on granulocyte adhesion during coronary angiography. We also evaluated the influence of the ionicity and osmolarity of the different substances on granulocyte adhesion molecules in in vitro experiments.
Results: The osmolarity of patient serum samples increased from 302 +/- 1 to 309 +/- 1 mOsm/kg (p < 0.05) after infusion of RCM. The CD11b expression in the samples of the non-ionic RCM treated group increased from 221 +/- 21 MFI to 377 +/- 30 MFI (p < 0.05) measured as the absolute mean fluorescence intensity (MFI), yet did not alter significantly in the ionic RCM group. In contrast, the in vitro experiments showed a reduction of the CD11b expression from 360 +/- 70 MFI to 149 +/- 30 MFI (p < 0.05) in the ionic RCM group.
Conclusions: The upregulation of adhesion molecules was significantly reduced in vivo with ionic RCM, while ionic substances caused opposite effects in vitro. This effect should be taken into account when performing leukocyte functional analysis of samples taken during angiography.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781624 | PMC |
| http://dx.doi.org/10.1080/09629350310001619690 | DOI Listing |
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