Purpose: The purpose of this study was to evaluate the ability of the Myocor Coapsys device to restore leaflet apposition and valve competency off-pump in a canine model of functional mitral regurgitation (MR).
Description: The Coapsys device was surgically implanted in 10 dogs after MR induction by rapid ventricular pacing. The Coapsys consists of anterior and posterior epicardial pads connected by a subvalvular chord. The annular head of the posterior pad was positioned at the annular level to draw the posterior leaflet and annulus toward the anterior leaflet. Final device size was selected when MR was minimized or eliminated as assessed by color flow Doppler echocardiography.
Evaluation: All implants were placed off-pump without atriotomy, and mean MR grade was reduced from 2.9 +/- 0.7 to 0.6 +/- 0.7 (p < 0.001) acutely. No hemodynamic compromise was noted.
Conclusions: The Coapsys device consistently and significantly reduced or eliminated functional MR acutely. Further study will be required to assess the chronic stability of the repair in this animal model.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/S0003-4975(03)01309-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: We sought to determine regional myofiber stress after Coapsys device (Myocor, Inc, Maple Grove, MN) implantation using a finite element model of the left ventricle (LV). Chronic ischemic mitral regurgitation is caused by LV remodeling after posterolateral myocardial infarction. The Coapsys device consists of a single trans-LV chord placed below the mitral valve such that when tensioned it alters LV shape and decreases chronic ischemic mitral regurgitation.
View Article and Find Full Text PDFOutcomes of the RESTOR-MV Trial (Randomized Evaluation of a Surgical Treatment for Off-Pump Repair of the Mitral Valve).
J Am Coll Cardiol
December 2010
New York University School of Medicine and New York Harbor Veterans Healthcare System, New York, New York 10028, USA.
Objectives: we sought to determine whether patients with functional mitral regurgitation (FMR) would benefit from ventricular reshaping by the Coapsys device (Myocor, Inc., Maple Grove, Minnesota).
Background: FMR occurs when ventricular remodeling impairs valve function.
Chronic ischaemic mitral regurgitation. Current treatment results and new mechanism-based surgical approaches.
Eur J Cardiothorac Surg
January 2010
Department of Cardiothoracic Surgery, University Medical Center Groningen, Groningen, The Netherlands.
Chronic ischaemic mitral regurgitation (CIMR) remains one of the most complex and unresolved aspects in the management of ischaemic heart disease. This review provides an overview of the present knowledge about the different aspects of CIMR with an emphasis on mechanisms, current surgical treatment results and new mechanism-based surgical approaches. CIMR occurs in approximately 20-25% of patients followed up after myocardial infarction (MI) and in 50% of those with post-infarct congestive heart failure (CHF).
View Article and Find Full Text PDFiCoapsys mitral valve repair system: Percutaneous implantation in an animal model.
Catheter Cardiovasc Interv
July 2008
Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Twin Cities Heart Foundation, Minneapolis, Minnesota 55407, USA.
Objective: Determine if the iCoapsys device could be accurately and safely implanted using a novel transcatheter system.
Background: Functional mitral regurgitation is a ventricular disease characterized by mitral insufficiency in the absence of structural valve abnormalities. It occurs in the presence of ischemic or non-ischemic cardiomyopathy.
Percutaneous and off-pump treatments for functional mitral regurgitation.
J Artif Organs
July 2008
Department of Biomedical Engineering / ND20, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
A new era in the treatment of functional mitral regurgitation is emerging with new devices that can be placed percutaneously or minimally invasively without cardiopulmonary bypass. These devices are categorized into three groups: annuloplasty, edge-to-edge repair, and ventricular reshaping. Percutaneous annuloplasty devices, implanted via the coronary sinus, mimic surgical annuloplasty by reducing the mitral annular anterior-posterior (or septal-lateral) dimension.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!