AI Article Synopsis
- In our study on the tropical plant Peucedanum japonicum, we isolated a new C(13) norisoprenoid glucoside and two new phenylpropanoid glucosides from the plant's leaves.
- The structure of these compounds was determined using spectroscopic techniques, and we also identified five known compounds during the process.
- We tested the isolated compounds for their antioxidant and tyrosinase inhibitory activities, finding that two specific compounds showed significant effects in both tests.
Article Abstract
In the course of our study on the isolation and structure determination of constituents in tropical plants, we focused on Peucedanum japonicum Thunb., belonging to the family Umbelliferae. In this study, a new C(13) norisoprenoid glucoside, (3S)-O-beta-d-glucopyranosyl-6-[3-oxo-(2S)-butenylidenyl]-1,1,5-trimethylcyclohexan-(5R)-ol (1), and two new phenylpropanoid glucosides, 3-(2-O-beta-d-glucopyranosyl-4-hydroxyphenyl)propanoic acid (3) and methyl 3-(2-O-beta-d-glucopyranosyl-4-hydroxyphenyl)propanoate (4), were isolated from the n-butanol soluble fraction of this plant's leaves, together with five known compounds. The structures of these compounds were determined on the basis of spectroscopic evidence. In addition, all isolated compounds were examined for scavenging activity against 1,1-diphenyl-2-picrylhydrazyl radical and inhibitory activity against mushroom tyrosinase. These results suggested that 2-(4-hydroxy-3-methoxyphenyl)propane-1,3-diol (7) and 3-O-beta-d-glucopyranosyl-2-(4-hydroxy-3-methoxyphenyl)propanol (8) showed an appreciable activity in both assay systems.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jf0349127 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of Apoptosis-Inducing Coumarins Isolated from Roots: The Potential for Leukemia Treatment via the Mitochondria-Mediated Pathway.
Cells
November 2024
Department of Biomedical Science, Sunchon National University, Suncheon 57922, Republic of Korea.
Inducing programmed cell death in tumors is a fundamental approach in cancer therapy, prompting extensive efforts to discover bioactive compounds with anticancer properties. , a plant used in traditional medicine across East Asia, has been reported to exhibit various biological activities, including anticancer effects. This study aimed to evaluate the apoptosis-inducing effects of methanol/dichloromethane (MeOH/CHCl) extracts of roots and their components in HL-60 human leukemia cells.
View Article and Find Full Text PDFRoot microbiome of Panax ginseng in comparison with three other medicinal plants in the families of Araliaceae and Apiaceae.
Sci Rep
December 2024
Department of Agricultural Biotechnology, Seoul National University, Seoul, Korea.
The intricate interplay between endophytic microorganisms and plants in the upkeep of biodiversity, the stability of communities, and the operation of ecosystems needs to be more adequately extensive. Although root-associated microbial communities of plants have been revealed for the last decade, the understanding of bacterial and fungal communities associated with the roots of medicinal plants remains elusive. To highlight the importance of Panax ginseng Meyer (PG) in our research, we investigated the root endophytic bacterial and fungal communities of Panax ginseng Meyer (PG), alongside Aralia cordata (AC), Angelica gigas (AG), and Peucedanum japonicum (PJ), utilizing amplicon-based community profiling and advanced bioinformatic methodologies.
View Article and Find Full Text PDFExploration of New Drug Candidate Derived from Antioxidants of Korean Native Halophytes: Control of with Antipathogenic Activity.
Antioxidants (Basel)
October 2024
Division of Convergence on Marine Science, Korea Maritime & Ocean University, Busan 49112, Republic of Korea.
The rise of antibiotic-resistant bacteria poses a significant challenge to the treatment of bacterial infections, necessitating the development of novel antibiotics or strategies to preserve the efficacy of existing ones. This study investigates the role of oxidative stress modulation in the pathogenicity of multidrug-resistant (MDR) bacterial strains, aiming to identify potential avenues for new drug design. Specifically, the anti-biofilm effects of crude extracts and fractions from seven halophyte species native to Jeju Island, South Korea, were evaluated against ATCC 17978.
View Article and Find Full Text PDFThe medicinal plant Peucedanum japonicum Thunberg: A review of traditional use, phytochemistry, and pharmacology.
Fitoterapia
December 2024
Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam; Department of Chemistry, Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam. Electronic address:
Peucedanum japonicum (the family Umbelliferae) is a perennial herbaceous plant with various crucial traditional values for coughs, colds, headaches, and inflammatory responses. For drug developments, the current research aims to offer an overview of the previous results in the three main aspects of traditional use, phytochemistry, pharmacological values, and molecular mechanisms regarding this medicinal species. By chromatographic analysis and separation, more than 120 isolated compounds have been obtained.
View Article and Find Full Text PDFComprehensive Determination of the Phenolic Compound Contents and Antioxidant Potentials of Leaves and Roots of Harvested from Different Accessions and Growth Periods.
ACS Omega
October 2024
Department of Plant Science and Technology, Chung-Ang University, Anseong 17546, Republic of Korea.
Thunberg, a medicinal plant, remains understudied despite its potential therapeutic benefits. This study aimed to determine the phytochemical profiles and antioxidant capacities in the extracts of different accessions of by measuring the total polyphenol and flavonoid content of the extracts coupled with DPPH and ABTS assays. In addition, phytochemical screening via LC-MS/MS and high-performance liquid chromatography analysis quantified nine compounds wherein chlorogenic acid (CA) was found to be the most abundant in all compounds while hyperoside and peucedanol were the least.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!