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[Alterations of inotropic function of isolated heart and extent of injury of cardiomyocytes after cannabinoid receptor activation during ischemia and reperfusion]. | LitMetric
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[Alterations of inotropic function of isolated heart and extent of injury of cardiomyocytes after cannabinoid receptor activation during ischemia and reperfusion].

L N Maslov O V Lasukova A V Krylatov Iu B Lishmanov R Pertwee

Ross Fiziol Zh Im I M Sechenova

Tomsk State Pedagogical University, Russia.

Published: September 2003

It was found that CB1- and CB2-receptor activation by intravenous administration of the selective CB-agonist HU-210 at a dose 0.1 mg/kg prompts an increase of myocardial resistance to the pathogenic action of ischemia and reperfusion in vitro. The revealed effects of HU-210 do not depend on the activation of CB-receptors in the myocardium.

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