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Ultrasound Characteristics Can Predict Response to Biologics Therapy in Stricturing Crohn's Disease.
Clin Transl Gastroenterol
August 2024
Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Article Synopsis
- Stricture, a common issue in Crohn's disease, can hinder effective treatment, making it crucial to identify which patients won't respond well to biologic therapy.
- This study analyzed ultrasound features of strictures in 43 patients, looking at factors like bowel wall thickness and creeping fat, to determine their association with treatment outcomes over at least a year.
- Findings indicated that specific ultrasound characteristics, especially a creeping fat wrapping angle greater than 180°, could predict the need for surgery and the likelihood of achieving steroid-free clinical remission in these patients.
Multimodal dynamic ultrasound approach as predictor of response in patients with Crohn's disease treated with ustekinumab.
Therap Adv Gastroenterol
June 2024
Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Università Cattolica del Sacro Cuore - Rome, Largo A. Gemelli, 8, Rome 00168, Italy.
Article Synopsis
- Ustekinumab (UST) has emerged as a new treatment option for Crohn's disease (CD), but there is a need for predictors of its effectiveness, with contrast-enhanced ultrasound (CEUS) being a promising non-invasive method.
- A study was conducted to evaluate the role of multimodal intestinal ultrasound (IUS) in predicting the treatment response to UST in CD patients who had previously undergone anti-TNFα therapy, assessing various parameters over time.
- Results showed that specific ultrasound measurements, particularly changes in bowel wall thickness and IUS score, effectively predicted long-term therapeutic outcomes in CD patients receiving UST, indicating the potential utility of IUS in clinical settings.
Flap Closure in Neonatal Neural Tube Defects: Challenges in Flap Design and Lessons Learnt.
J Indian Assoc Pediatr Surg
March 2024
Department of Community Medicine, Pt. JNM Medical College, Raipur, Chhattisgarh, India.
Background: Management of neural tube defects (NTDs) is challenging and the outcome is demanding.
Aims: To analyze the outcomes in operated cases of NTDs closed using various types of flaps.
Materials And Methods: The data between June 2017 and May 2023 were analyzed.
Bichloride-based ionic liquids for the merged storage, processing, and electrolysis of hydrogen chloride.
Sci Adv
April 2024
Freie Universität Berlin, Institut für Anorganische Chemie, Fabeckstr. 34/36, 14195 Berlin, Germany.
Hydrogen chloride is produced as a by-product in industrial processes on a million-ton scale. Since HCl is inherently dangerous, its storage and transport are avoided by, e.g.
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