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A decade of real-world clinical experience with 8-week azithromycin-metronidazole combined therapy in paediatric Crohn's disease.
J Pediatr Gastroenterol Nutr
December 2024
Department of Paediatric Gastroenterology and Nutrition, Royal Hospital for Children and Young People, Edinburgh, UK.
Objectives: The aim of our study was to assess the effectiveness and side-effect profile of a combination of azithromycin and metronidazole (CD AZCRO) as alternative induction therapy for 8 weeks in mild to moderately active paediatric Crohn's disease (CD).
Methods: We performed a retrospective cohort study (November 2012 to July 2023) of a regional paediatric inflammatory bowel disease service. Disease activity, faecal calprotectin (FC), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), haematological parameters and albumin were collected at baseline, 8 and 16 weeks.
Diagnosis and clinical management of drug allergies in obstetrics and gynecology: an expert review.
Am J Obstet Gynecol
October 2024
Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT. Electronic address:
Article Synopsis
- Drug allergies, especially to antibiotics like penicillin, are common in obstetrics and gynecology, affecting about 10% of the US population and complicating treatment options for infections.
- Using alternative antibiotics due to reported allergies can lead to significant complications such as increased surgery rates, longer hospital stays, and higher healthcare costs, plus a risk of severe reactions like anaphylaxis.
- More than 90% of those who claim a penicillin allergy can actually tolerate it, so allergy evaluations—including patient histories and tests—are recommended to ensure appropriate use of first-line antibiotics during pregnancy and beyond.
Investigating FSGS-like injury in zebrafish larvae by nifurpirinol: efficacy and molecular insight.
Am J Physiol Renal Physiol
September 2024
Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.
Identifying effective drugs for focal segmental glomerulosclerosis (FSGS) treatment holds significant importance. Our high-content drug screening on zebrafish larvae relies on nitroreductase/metronidazole (NTR/MTZ)-induced podocyte ablation to generate FSGS-like injury. A crucial factor for successful drug screenings is minimizing variability in injury induction.
View Article and Find Full Text PDFUnraveling Verapamil's Multidimensional Role in Diabetes Therapy: From β-Cell Regeneration to Cholecystokinin Induction in Zebrafish and MIN6 Cell-Line Models.
Cells
May 2024
Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Dasman 15462, Kuwait.
This study unveils verapamil's compelling cytoprotective and proliferative effects on pancreatic β-cells amidst diabetic stressors, spotlighting its unforeseen role in augmenting cholecystokinin (CCK) expression. Through rigorous investigations employing MIN6 β-cells and zebrafish models under type 1 and type 2 diabetic conditions, we demonstrate verapamil's capacity to significantly boost β-cell proliferation, enhance glucose-stimulated insulin secretion, and fortify cellular resilience. A pivotal revelation of our research is verapamil's induction of CCK, a peptide hormone known for its role in nutrient digestion and insulin secretion, which signifies a novel pathway through which verapamil exerts its therapeutic effects.
View Article and Find Full Text PDFAntibiotics-Induced Intestinal Immunomodulation Attenuates Experimental Autoimmune Neuritis (EAN).
J Neuroimmune Pharmacol
May 2024
Department I of Internal Medicine, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany.
The composition of gut microbiota plays a pivotal role in priming the immune system and thus impacts autoimmune diseases. Data on the effects of gut bacteria eradication via systemic antibiotics on immune neuropathies are currently lacking. This study therefore assessed the effects of antibiotics-induced gut microbiota alterations on the severity of experimental autoimmune neuritis (EAN), a rat model of Guillain-Barré Syndrome (GBS).
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