AI Article Synopsis
- The study explores how dynamic activities at the synapse level affect the rapid reorganization of sensory maps in the brain.
- Using a computational model that simulates the primary somatosensory system, researchers linked the interactions between excitatory and inhibitory neurons to changes in the brain after a peripheral injury.
- The model includes tactile receptors, thalamic nuclei, and cortical areas to mimic the brain's connections and applies informational measures to understand how synaptic elements contribute to hand map reorganization in the cortex.
Article Abstract
In this work we study the connection between some dynamic effects at the synaptic level and fast reorganization of cortical sensory maps. By using a biologically plausible computational model of the primary somatosensory system we obtained simulation results that can be used to relate the dynamics of the interactions of excitatory and inhibitory neurons to the process of somatotopic map reorganization immediately after peripheral lesion. The model consists of three regions integrated into a single structure: tactile receptors representing the glabrous surface of the hand, ventral posterior lateral nucleus of the thalamus and area 3b of the primary somatosensory cortex, reproducing the main aspects of the connectivity of these regions. By applying informational measures to the simulation results of the dynamic behavior of AMPA, NMDA and GABA synaptic conductances we draw some conjectures about how the several neuronal synaptic elements are related to the initial stage of the digit-induced reorganization of the hand map in the somatosensory cortex.
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| http://dx.doi.org/10.1023/B:JCNS.0000014109.83574.78 | DOI Listing |
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