1. As they grow, the dental germs build their chamber, exerting tensions on a fibrillar structure facing their occlusal side or incisive edge. This structure now stretches the circular margin of the alveolus, made of chondroïd tissue. 2. The maxillary bases, of negligible volume during foetal formation and prime infancy, have to be considered as adaptive structures among genetically determined growth factors: brain, basicranium and a number of dental germs. Those factors are the real agents forming the face. 3. In case of malformation due to a lack of space, the wording "cranio-dental dysharmony" seems to be more adequate than "dento-maxillary dysharmony".
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J Oral Biosci
December 2024
Department of Maxillofacial Orthognathics, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45, Bunkyo-ku, Tokyo, 113-8549, Japan.
Objectives: To investigate the effects of hypoxia on tooth germ development in mice and explore the underlying mechanisms.
Methods: Tooth germs were extracted from E14.5 mouse embryos and divided into the control and hypoxia groups for organ culture.
Zhonghua Kou Qiang Yi Xue Za Zhi
January 2025
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan430079, China.
J Oral Biosci
December 2024
Division of Anatomical and Cellular Pathology, Department of Pathology, Iwate Medical University, 1-1-1 Idaidori, Yahaba-cho, Shiwa-gun, Iwate, 028-3694, Japan. Electronic address:
Objective: This study aimed to evaluate the role of the chromodomain helicase DNA-binding protein 3 (CHD3) in tooth morphogenesis in Chd3 knockout mice.
Methods: Chd3 knockout mice were generated using the CRISPR-Cas9 method. Mandibular first molars were extracted from the mice and their littermates and morphometrically analyzed.
Cureus
October 2024
Department of Periodontology and Dental Implantology, Medical University of Varna, Varna, BGR.
Background and objective Enamel matrix derivatives (EMD) are biomaterials extracted from porcine dental germs. They consist of amelogenins (90%), ameloblastine, enamelin, and amelotin. New evidence has shown that all these proteins can be absorbed onto hydroxyapatite crystals and collagen fibers on the root surface of teeth and initiate regeneration of root cementum as well as stimulate periodontal cell proliferation.
View Article and Find Full Text PDFInt J Paediatr Dent
November 2024
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Background: Dens evaginatus is a dental morphological developmental anomaly. Failing to detect it may lead to tubercles fracture and pulpal/periapical disease. Consequently, early detection and intervention of dens evaginatus are significant to preserve vital pulp.
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