The discovery and development of substances require new forms at a level which was considered satisfactory a few years ago. The research on secondary effects and drugs optimizations to new pharmaceutical forms. So, we can speak about the inclusion complexes. The purpose of the paper was to describe the cyclodextrins properties, the complexation process and the most important analysis methods for complexes between cyclodextrins and drugs.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Aggregation-induced emission and absorption enhancement of mixed-valent rhenium oxide quantum dots by triethylamine: Implications for food safety monitoring.
J Hazard Mater
December 2024
Department of Chemistry, National Sun Yat-sen University, No. 70 Lienhai Rd., Kaohsiung 80424, Taiwan; Center for Nanoscience & Nanotechnology, National Sun Yat-sen University, No. 70 Lienhai Rd., Kaohsiung 80424, Taiwan; School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, No.100, Shiquan 1st Rd., Kaohsiung 80708, Taiwan. Electronic address:
Food freshness monitoring and volatile amine detection are key to food safety. In this study, we demonstrated the applicability of mixed-valence rhenium oxide quantum dots (MV-ReOQDs), synthesized via the hydrothermal reaction of α-cyclodextrin and rhenium ion precursors, in triethylamine (TEA) sensing. Spectroscopic correlation techniques showed that the developed MV-ReOQDs possessed mixed-valent rhenium, α-cyclodextrin as capped ligand, partially carbonized surface, and amorphous phase structure.
View Article and Find Full Text PDFInstationary metabolic flux analysis reveals that NPC1 inhibition increases glycolysis and decreases mitochondrial metabolism in brain microvascular endothelial cells.
Neurobiol Dis
January 2025
Department of Bioengineering, University of Maryland, College Park, MD 20742, United States of America. Electronic address:
Niemann Pick Disease Type C (NP-C), a rare neurogenetic disease with no known cure, is caused by mutations in the cholesterol trafficking protein NPC1. Brain microvascular endothelial cells (BMEC) are thought to play a critical role in the pathogenesis of several neurodegenerative diseases; however, little is known about how these cells are altered in NP-C. In this study, we investigated how NPC1 inhibition perturbs BMEC metabolism in human induced pluripotent stem cell-derived BMEC (hiBMEC).
View Article and Find Full Text PDFA comprehensive review of β-cyclodextrin polymer nanocomposites exploration for heavy metal removal from wastewater.
Carbohydr Polym
February 2025
Department of Materials Science and Nanotechnology Engineering, Usak University, 64200 Usak, Turkey.
This review focuses on the application of β-cyclodextrin (β-CD) polymer nanocomposites (NCs) in the heavy metals (HMs) removal from contaminated water sources. This manuscript's originality consists of an in-depth analysis of recent advances in using β-cyclodextrin nanocomposites (β-CD-NCs) to remove HMs from wastewater, highlighting literature gaps, innovations, and challenges in this field, suggesting perspectives on existing theories, and outlining implications for future research directions. Combining nanoparticles with the β-CD polymer yields stable, reusable β-CD-NCs that are effective and efficient in HM adsorption.
View Article and Find Full Text PDFTargeting autophagy in HCC treatment: exploiting the CD147 internalization pathway.
Cell Commun Signal
December 2024
Department of Cell Biology, National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Background/aims: Chemotherapy resistance in liver cancer is a major clinical issue, with CD147 playing a vital role in this process. However, the specific mechanisms underlying these processes remain largely unknown. This study investigates how CD147 internalization leads to cytoprotective autophagy, contributing to chemotherapy resistance in hepatocellular carcinoma (HCC).
View Article and Find Full Text PDFCucurbit[7]uril and β-cyclodextrin as hosts for dopamine: complexation, affinity, and computational insights.
J Biomol Struct Dyn
December 2024
Department of Chemistry, Faculty of Science, The Hashemite University, Zarqa, Jordan.
Dopamine (DP), an essential neurotransmitter implicated in diverse brain functions, was investigated as a guest molecule within the host cavities of cucurbit[7]uril (CB7) and β-cyclodextrin (βCD) using isothermal titration calorimetry (ITC), UV-titration, H NMR, molecular dynamics (MD) and density functional theory (DFT) calculations. The experimentally estimated binding constants of the 1:1 complexes of DP with CB7 and βCD were found to be 5.3 × 10 and 2.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!