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Hypoxia-Initiated Supramolecular Free Radicals Induce Intracellular Polymerization for Precision Tumor Therapy.
J Am Chem Soc
January 2025
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, and MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau SAR 999078, China.
Despite the development of various controlled release systems for antitumor therapies, off-target side effects remain a persistent challenge. In situ therapeutic synthesis from biocompatible substances offers a safer and more precise alternative. This study presents a hypoxia-initiated supramolecular free radical system capable of inducing intracellular polymerization, thereby disrupting the cytoskeleton and organelles within 4T1 cells.
View Article and Find Full Text PDFOptimal Synergy between Azulenes and Acenes in Azuacenes with 6-7-5 Ring Topology.
J Am Chem Soc
January 2025
Department of Physical Chemistry, University of Malaga, Campus de Teatinos s/n, Málaga 29071, Spain.
Azuacenes, defined as azulene fused with acenes in a 6-7-5 ring topology and spanning lengths from 3 to 6 rings, have been synthesized using a new skeleton editing and [3 + 2] annulation synthesis protocol as a distinction regarding the procedures to obtain the 6-5-7 isomers. Comprehensive studies on ground-state and excited-state spectroscopy, electrochemical properties, chemical stability, and solid-state structure have been conducted to compare these azuacenes with acenes. For the same number of rings, we found that azuacenes improve the chemical stability of acenes (i.
View Article and Find Full Text PDFA trimetallic bismuth(I)-based allyl cation.
Nat Chem
January 2025
Max-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr, Germany.
The chemistry of low-valent bismuth compounds has recently unlocked new concepts in catalysis and unique electronic structure fundamentals. In this work, we describe the synthesis and characterization of a highly reduced bismuth salt featuring a cationic core based on three contiguous Bi(I) centres. The triatomic bismuth-based core exhibits an electronic configuration that mimics the canonical description of the archetypical carbon-based π-allyl cation.
View Article and Find Full Text PDFDesign and Regulation of Anthraquinone's Electrochemical Properties in Aqueous Zinc-Ion Batteries via Benzothiadiazole and Its Dinitro Derivatives.
ACS Appl Mater Interfaces
January 2025
Key Laboratory of Functional Inorganic Material Chemistry, Ministry of Education, and Department of Macromolecular Science and Engineering, School of Chemistry and Chemical Engineering, Heilongjiang University, Harbin 150080, P. R. China.
Article Synopsis
- Organic cathode materials are promising for aqueous zinc-ion batteries (AZIBs) due to their low cost and tunable properties, with benzothiadiazoles showing potential for effective electron acceptance.
- A new polymer, PBDQ-N, was designed by adding nitro groups to enhance electron delocalization and increase active sites, resulting in better zinc-ion insertion/extraction.
- PBDQ-N exhibited exceptional electrochemical performance with a specific capacity of 446.2 mAh/g and a cycle life of over 20,000 cycles, highlighting the importance of molecular design in optimizing battery materials.
Through Space π-Electrons Communication in [2,2]-Paracyclophanes: Unprecendented Stabilization of Radicals.
Angew Chem Int Ed Engl
December 2024
Aix Marseille Univ, CNRS, ICR UMR 7273, 13013, Marseille, France.
Efforts to understand radical stability have led to considerable progress in radical chemistry. In this article, we investigated a novel approach to enhancing the radical stability of carbon-centered radicals through space electron delocalization within [2,2]-paracyclophanes. Alkoxyamines possessing a paracyclophane scaffold exploit face-to-face π-π-interactions between the aromatic rings to effectively lower bond dissociation energy (BDE) for NO-C bond homolysis.
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