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TRB3 Promotes Cataract Progression through Endoplasmic Reticulum Stress-mediated Mitochondrial Dysfunction and Cell Apoptosis.
Cell Biochem Biophys
August 2024
Department of Ophthalmology, The Second Affiliated Hospital of Kunming Medical University, Kunming, 650000, China.
Cataracts are characterized as a disease affecting lens opacity. Endoplasmic reticulum (ER) stress can cause lens epithelial cell (LEC) dysfunction, affecting normal lens transparency and function, but the role of Tribbles 3 (TRB3), an inducible gene of ER stress, in cataracts is poorly understood. This study explored how TRB3 promotes cataract progression through ER stress.
View Article and Find Full Text PDFThe impact of lutein-loaded poly(lactic-co-glycolic acid) nanoparticles following topical application: An in vitro and in vivo study.
PLoS One
August 2024
Department of Biological and Agricultural Engineering, Louisiana State University, Baton Rouge, Louisiana, United States of America.
Antioxidant therapies are of interest in the prevention and management of ocular disorders such as cataracts. Although an active area of interest, topical therapy with antioxidants for the treatment of cataracts is complicated by multiple ocular anatomical barriers, product stability, and solubility. Entrapment and delivery of antioxidants with poly(lactic-co-glycolic acid) nanoparticles is a possible solution to these challenges, however, little is known regarding their effects in vitro or in vivo.
View Article and Find Full Text PDFEffects of Eye Drop on Selenite-Induced Cataract Formation and Oxidative Stress-Related Parameters in Rabbits: An Experimental Study.
Curr Eye Res
December 2024
Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples "Federico II", Naples, Italy.
Purpose: To evaluate the protective role of eye drops on selenite-induced cataracts in suckling rabbits.
Methods: Fifteen male albino suckling rabbits with no signs of ocular inflammation were randomly assigned to three groups: controls (Group A), sodium-selenite group (Group B) and sodium-selenite plus group (Group C). By selenite treatment, cataract formation was experimentally induced and then graded.
SIRT1 inhibits apoptosis of human lens epithelial cells through suppressing endoplasmic reticulum stress and .
Int J Ophthalmol
July 2024
Senior Department of Ophthalmology, the Third Medical Center of PLA General Hospital, Beijing 100853, China.
Aim: To explore the effect of silent information regulator factor 2-related enzyme 1 (SIRT1) on modulating apoptosis of human lens epithelial cells (HLECs) and alleviating lens opacification of rats through suppressing endoplasmic reticulum (ER) stress.
Methods: HLECs (SRA01/04) were treated with varying concentrations of tunicamycin (TM) for 24h, and the expression of SIRT1 and C/EBP homologous protein (CHOP) was assessed using real-time quantitative polymerase chain reaction (RT-PCR), Western blotting, and immunofluorescence. Cell morphology and proliferation was evaluated using an inverted microscope and cell counting kit-8 (CCK-8) assay, respectively.
Animal model for in-vivo Nuclear Cataract. Lens hardness and elasticity assessment.
J Mech Behav Biomed Mater
September 2024
Department of Electrical and Computer Engineering, Univ Coimbra, Portugal.
Age-related cataract is the most frequent cause of blindness in the world being responsible for 48% of blindness and affecting more than 10% of the working population. Currently there is no objective data of the lens biomechanical properties so the process by which the cataract affects the lens's properties (e.g.
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