Inactivation of transmissible spongiform encephalopathy (prion) agents by environ LpH.

J Virol

Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.

Published: February 2004

Agents causing transmissible spongiform encephalopathy (TSE) diseases are resistant to inactivation by several conventional decontamination methods. Using an animal bioassay, we compared the TSE agent disinfectant efficacy of a commercially available product referred to alternatively as LpH-SE, LpH-AG, or LpH-st to that of a similarly named but differently formulated product, Environ LpH, which was found to be an effective TSE agent disinfectant in a previous study. Here, we found LpH-SE to be at least 10(4)-fold to 10(5)-fold less effective than Environ LpH.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC369477PMC
http://dx.doi.org/10.1128/jvi.78.4.2164-2165.2004DOI Listing

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