The lipid-destabilizing properties of the N-terminal domain of the GP2 of Ebola virus were investigated. Our results suggest that the domain of Ebola virus needed for fusion is shorter than that previously reported. The fusogenic properties of this domain are related to its oblique orientation at the lipid/water interface owing to an asymmetric distribution of the hydrophobic residues when helical.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC369453 | PMC |
| http://dx.doi.org/10.1128/jvi.78.4.2131-2136.2004 | DOI Listing |
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