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Spontaneous tumour lysis syndrome in chronic lymphocytic leukaemia: an unanticipated complication of an undiagnosed disease.
BMJ Case Rep
November 2024
Medicine, Government Medical College Kota, Kota, Rajasthan, India.
Spontaneous tumour lysis syndrome (STLS) is a rare oncological emergency characterised by the spontaneous destruction of tumour cells in the absence of chemotherapy, with the release of large amounts of intracellular ions and metabolic products leading to organ damage and at times death. In chronic lymphocytic leukaemia (CLL), historically, tumour lysis syndrome has been rarely observed owing to low rate of proliferation and slow response to chemotherapy. We report a rare case of STLS in underlying undiagnosed CLL.
View Article and Find Full Text PDFImmunophenotypic properties association of CLL and ALL patient cells by flow cytometry analysis.
J Taibah Univ Med Sci
October 2024
Department of Biology, College of Science, Salahaddin University-Erbil, Erbil, Kurdistan Region, Iraq.
Article Synopsis
- Chronic lymphocytic leukemia (CLL) and acute lymphoblastic leukemia (ALL) are blood cancers affecting lymphocytes, which can be diagnosed through flow cytometry, focusing on cell surface markers like CD19.
- The study aimed to analyze the relationship between CD19-positive cell counts and other CD antigens in patients diagnosed with CLL and ALL.
- Results indicated that while age and sex did not impact CD19-positive cell counts, CLL patients showed strong correlations between CD19 and other markers (CD5, CD20, CD23, CD200), while ALL patients showed similar correlations with CD79 and CD99, with higher CD19 counts observed in both groups.
Dysregulated MicroRNAs in Chronic Lymphocytic Leukemia.
Cureus
September 2024
Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, ROU.
MiRNAs are a class of non-coding RNAs acting as gene expression regulators by modulating the lifespan of messenger RNA. Commonly referred to as the most frequent leukemia in the Western world, chronic lymphocytic leukemia (CLL) is a lymphoproliferative malignancy characterized by clonal expansion of CD19, CD23, and CD5-positive mature B-cells. While this pathology is regarded as less aggressive and has a variety of treatment options, the cause of its clinical heterogeneity is not yet understood.
View Article and Find Full Text PDFContributions of each of the BAFF receptors to the lymphocyte profiles in C57BL/6 mice.
Immunology
December 2024
New York State Psychiatric Institute, New York, New York, USA.
BAFF, a vital B cell survival and differentiation factor, has three receptors: B-cell maturation antigen (BCMA), transmembrane activator and CAML interactor (TACI) and BR3. Although B cells are greatly reduced in B6.Baff (which harbour no BAFF) and B6.
View Article and Find Full Text PDFDUSP1 and SOX2 expression determine squamous cell carcinoma of the salivary gland progression.
Sci Rep
July 2024
Laboratory of Translational Research in Maxillofacial Surgery and Head and Neck Cancer, IdiPAZ, 28046, Madrid, Spain.
Salivary gland squamous cell carcinomas (SG-SCCs) constitute a rare type of head and neck cancer which is linked to poor prognosis. Due to their low frequency, the molecular mechanisms responsible for their aggressiveness are poorly understood. In this work we studied the role of the phosphatase DUSP1, a negative regulator of MAPK activity, in controlling SG-SCC progression.
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