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Loneliness among Adults Aging with Intellectual and Developmental Disabilities: The Importance of Living Situation.
Gerontologist
January 2025
Department of Gerontology, Donna M. and Robert J. Manning College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, Massachusetts, USA.
Background And Objectives: Loneliness is a serious public health concern among the aging population. Not only is loneliness an unpleasant emotional experience, it is also associated with worse health, well-being, and even mortality. This is a particularly important issue among the population aging with intellectual and developmental disabilities, who are more likely to experience loneliness across the life course, and who - particularly if living in an intermediate care facility (ICF) or nursing facility - may lack social connections.
View Article and Find Full Text PDFThe hippocampus forms memories of our experiences by registering processed sensory information in coactive populations of excitatory principal cells or ensembles. Fast-spiking parvalbumin-expressing inhibitory neurons (PV INs) in the dentate gyrus (DG)-CA3/CA2 circuit contribute to memory encoding by exerting precise temporal control of excitatory principal cell activity through mossy fiber-dependent feed-forward inhibition. PV INs respond to input-specific information by coordinating changes in their intrinsic excitability, input-output synaptic-connectivity, synaptic-physiology and synaptic-plasticity, referred to here as experience-dependent PV IN plasticity, to influence hippocampal functions.
View Article and Find Full Text PDFPyriproxyfen, villain or good guy? A brief review.
Arch Endocrinol Metab
January 2025
Universidade Federal do Rio de Janeiro Instituto de Ciências Biomédicas Laboratório de Endocrinologia Experimental Rio de JaneiroRJ Brasil Laboratório de Endocrinologia Experimental (LEEx), Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
Pyriproxyfen (PPF) acts as a juvenile growth regulator, interfering with normal metamorphosis and blocking the development of insects into adulthood. Although the World Health Organization (WHO) considers the use of PPF at a concentration of 0.01 mg/L as unlikely to pose health risks, recent studies have unveiled potential risks associated with PPF exposure to non-target organisms.
View Article and Find Full Text PDFBehavioural Changes of Late Talkers During the Covid-19 Pandemic, One Year Follow-Up From a Community Sample.
J Paediatr Child Health
January 2025
Department of Pediatrics, Division of Developmental Pediatrics, Gazi University Faculty of Medicine, Ankara, Turkey.
Aim: Global threats to child health and well-being, compounded by the COVID-19 pandemic, have put child development at grave risk. This study aimed to observe the behavioural changes of children with isolated language delays from a paediatric outpatient clinic as a community sample during the pandemic with a 1-year follow-up.
Methods: Patients admitted to the paediatrics outpatient clinic due to isolated language delays were included in the study.
Olfactory testing in infants with perinatal asphyxia: enhancing encephalopathy risk stratification for future health outcomes.
Neurosci Biobehav Rev
January 2025
Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Viale delle Scienze 11, 43125 Parma, Italy.
Perinatal asphyxia (PA) is a leading cause of neonatal morbidity and mortality, often resulting in long-term neurodevelopmental challenges. Despite advancements in perinatal care, predicting long-term outcomes remains difficult. Early diagnosis is essential for timely interventions to reduce brain injury, with tools such as Magnetic Resonance Imaging, brain ultrasound, and emerging biomarkers playing a possible key role.
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