The properties of neutrophils, the parameters of lipid peroxidation, and the characteristics of antioxidant protection (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity) were studied in the blood of patients with duodenal ulcer and pancreatitis in the course of quamatel administration. The pattern of changes induced by quamatel shows evidence of the antioxidant activity of the drug.
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Anticancer Agents Med Chem
January 2025
Department of Basic Medical Sciences, Vision Colleges, Riyadh, 11451, Saudi Arabia.
Background: Liver fibrosis represents a serious risk to global health by impairing quality of life and elevating the chances of hepatocellular carcinoma, while the intricate role of autophagy can either alleviate or worsen fibrosis depending on its functioning.
Objective: Herein, we aimed to investigate the therapeutic effect of chlorogenic acid in CCl4-induced hepatic fibrosis and explore the autophagy pathway as the possible molecular target of chlorogenic acid.
Methods: Rats were injected with carbon tetrachloride (1ml/kg) to induce liver fibrosis for 10 weeks.
Diabetol Metab Syndr
January 2025
Department of Endocrinology, The Second People's Hospital of Yunnan Province, The Affiliated Hospital of Yunnan University, Kunming, Yunnan, 650021, China.
Background And Aim: Visceral fat (VF) was proved to be a more precise predictor of atherosclerotic cardiovascular disease (ASCVD) risk in individuals with type 2 diabetes mellitus (T2DM) than body mass index (BMI) itself. Even when the BMI was normal, visceral fat area (VFA) ≥ 90 cm² could raise the ten-year risk of developing ASCVD. Therefore, it was worth evaluating the association of influencing factors with high VF in non-obese T2DM individuals.
View Article and Find Full Text PDFBMC Gastroenterol
January 2025
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, No#44, Hojjatdoust St., Naderi St., Keshavarz Blvd, Tehran, 141556117, Iran.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease and can affect individuals without producing any symptoms. We aimed to explore the value of serum sirtuin-1 (Sirt-1) in the diagnosis of MASLD.
Methods: This case-control study analyzed data collected from 190 individuals aged 20 to 60 years.
BMC Pediatr
January 2025
Department of Cardiology, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Background: Hypertension has shown a trend of prevalence at younger ages, and the non-dipping pattern is associated with target organ damage in hypertension. However, few studies have yet investigated the clinical characteristics and risk factors of non-dipper status in essential hypertension children. This study aimed to explore the clinical characteristics and possible indicators associated with non-dipper status in children with essential hypertension.
View Article and Find Full Text PDFTransplantation
January 2025
Faculty of Medicine and Health, University of Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
Background: Simultaneous pancreas-kidney (SPK) transplantation is an effective treatment option for type 1 diabetes mellitus and concurrent end-stage kidney disease. However, the diabetogenic effects of immunosuppression can counteract the beneficial effects of sustained normoglycemia. Long-term metabolic trends that reflect cardiovascular risk are reported poorly in the literature.
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