AI Article Synopsis
- Germinal matrix-intraventricular hemorrhage (GMH-IVH) occurs in premature newborns due to the rupture of delicate capillaries, influenced by factors like cerebral blood flow fluctuations and microvascular weaknesses.
- Preventative interventions can help reduce the risk of GMH-IVH, while outcomes are largely affected by the severity of the hemorrhage and related complications, such as posthemorrhagic hydrocephalus.
- Very low birth weight (VLBW) infants often experience ongoing academic and behavioral challenges into adolescence, even if they show no neuroimaging abnormalities.
Article Abstract
Germinal matrix-intraventricular hemorrhage (GMH-IVH) in the premature newborn results from rupture of fragile capillaries in the germinal matrix. Its pathogenesis is multifactorial and relates principally to a pressure-passive cerebral circulation, fluctuations in cerebral blood flow, and derangements of coagulation and fragility of the germinal matrix microvasculature. Several interventions have beneficial effects for prevention of GMH-IVH. Outcome after GMH-IVH relates largely to the severity of hemorrhage, the extent of hemorrhagic and ischemic parenchymal involvement, and complications (e.g., posthemorrhagic hydrocephalus). Even in the absence of neuroimaging abnormalities, VLBW infants have a high incidence of academic and behavioral problems which persist into adolescence and early adulthood.
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| http://dx.doi.org/10.1016/s0733-8619(03)00067-7 | DOI Listing |
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