Recently, we reported that Streptococcus pyogenes kills Caenorhabditis elegans by the use of hydrogen peroxide (H2O2). Here we show that diverse streptococcal species cause death of C. elegans larvae in proportion to the level of H2O2 produced. H2O2 may mask the effects of other pathogenicity factors of catalase-negative bacteria in the C. elegans infection model.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC321644PMC
http://dx.doi.org/10.1128/IAI.72.2.1192-1194.2004DOI Listing

Publication Analysis

Top Keywords

caenorhabditis elegans
8
streptococcal species
8
hydrogen peroxide-mediated
4
peroxide-mediated killing
4
killing caenorhabditis
4
elegans
4
elegans common
4
common feature
4
feature streptococcal
4
species reported
4

Similar Publications

Aims: To investigate the effects of Lactococcus lactis subsp. lactis strains LL100933 and LL12007 on the host defense mechanisms of Caenorhabditis elegans against pathogenic infections and stressors.

Methods And Results: C.

View Article and Find Full Text PDF

Antioxidant and anti-aging activities of Acanthopanax senticosus polysaccharide CQ-1 in nematode Caenorhabditis elegans.

Int J Biol Macromol

January 2025

Shandong Provincial Third Hospital, Shandong University, Jinan 250031, China; Department of Microbiology and Synthetic Biology, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

Acanthopanax senticosus is a typical food medicine homology in China. The antioxidant and anti-aging activities of A. senticosus polysaccharides, especially the purified polysaccharide, have not been thoroughly investigated.

View Article and Find Full Text PDF

Short- and long-range roles of UNC-6/Netrin in dorsal-ventral axon guidance in vivo in Caenorhabditis elegans.

PLoS Genet

January 2025

Department of Molecular Biosciences, Program in Molecular, Cellular, and Developmental Biology, KU Center for Genomics, University of Kansas, Lawrence, Kansas, United States of America.

Recent studies in vertebrates and Caenorhabditis elegans have reshaped models of how the axon guidance cue UNC-6/Netrin functions in dorsal-ventral axon guidance, which was traditionally thought to form a ventral-to-dorsal concentration gradient that was actively sensed by growing axons. In the vertebrate spinal cord, floorplate Netrin1 was shown to be largely dispensable for ventral commissural growth. Rather, short range interactions with Netrin1 on the ventricular zone radial glial stem cells was shown to guide ventral commissural axon growth.

View Article and Find Full Text PDF

Brain-inspired wiring economics for artificial neural networks.

PNAS Nexus

January 2025

School of Physical Science and Engineering, Tongji University, Shanghai 200092, P. R. China.

Wiring patterns of brain networks embody a trade-off between information transmission, geometric constraints, and metabolic cost, all of which must be balanced to meet functional needs. Geometry and wiring economy are crucial in the development of brains, but their impact on artificial neural networks (ANNs) remains little understood. Here, we adopt a wiring cost-controlled training framework that simultaneously optimizes wiring efficiency and task performance during structural evolution of sparse ANNs whose nodes are located at arbitrary but fixed positions.

View Article and Find Full Text PDF

Male sex determination maintains proteostasis and extends lifespan of daf-18/PTEN deficient C. elegans.

EMBO Rep

January 2025

The Zhongzhou Laboratory for Integrative Biology, Henan University, 450000, Zhengzhou, Henan, China.

Although females typically have a survival advantage, those with PTEN functional abnormalities face a higher risk of developing tumors than males. However, the differences in how each sex responds to PTEN dysfunction have rarely been studied. We use Caenorhabditis elegans to investigate how male and hermaphrodite worms respond to dysfunction of the PTEN homolog daf-18.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!