A class of betulinic acid derivatives was synthesized to target two critical steps in the human immunodeficiency virus type 1 (HIV-1) replication cycle, entry and maturation. Each mechanism of HIV-1 inhibition is distinct from clinically available anti-HIV therapeutics. The viral determinants of the antientry and antimaturation activities are the bridging sheet of HIV-1 gp120 and the P24/p2 cleavage site, respectively.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC321552 | PMC |
| http://dx.doi.org/10.1128/AAC.48.2.663-665.2004 | DOI Listing |
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