AI Article Synopsis
- The study examined how quickly mutations that confer resistance to antiretroviral drugs change back to normal after stopping treatment.
- It found that the return to non-resistant (wild-type) amino acids occurred fastest with protease inhibitors.
- For nonnucleoside reverse transcriptase inhibitors, the change happened at a moderate pace, while for nucleoside reverse transcriptase inhibitors, the shift was the slowest.
Article Abstract
The dynamics of mutations associated with resistance to antiretroviral drugs were analyzed after cessation of therapy. The results showed that the kinetics of the shift to wild-type amino acid residues were significantly faster for protease inhibitors, intermediate for nonnucleoside reverse transcriptase inhibitors, and slower for nucleoside reverse transcriptase inhibitors.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC321535 | PMC |
| http://dx.doi.org/10.1128/AAC.48.2.644-647.2004 | DOI Listing |
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