Moxifloxacin penetration in bronchial secretions of mechanically ventilated patients with pneumonia.

Antimicrob Agents Chemother

Department of Anesthesiology and Intensive Care Unit and Trauma Center, Nord Hospital, Marseilles, France.

Published: February 2004

The pharmacokinetics of moxifloxacin was studied in 17 mechanically ventilated patients with pneumonia. Patients were given 400 mg of moxifloxacin intravenously. Blood samples and bronchial secretions were taken on days 1 and 4. A dose of 400 mg of moxifloxacin allows one to achieve efficient concentrations in bronchial secretions and plasma.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC321546PMC
http://dx.doi.org/10.1128/AAC.48.2.638-640.2004DOI Listing

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