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Orally active fusion inhibitor of respiratory syncytial virus. | LitMetric

AI Article Synopsis

Article Abstract

BMS-433771 was found to be a potent inhibitor of respiratory syncytial virus (RSV) replication in vitro. It exhibited excellent potency against multiple laboratory and clinical isolates of both group A and B viruses, with an average 50% effective concentration of 20 nM. Mechanism-of-action studies demonstrated that BMS-433771 inhibits the fusion of lipid membranes during both the early virus entry stage and late-stage syncytium formation. After isolation of resistant viruses, resistance was mapped to a series of single amino acid mutations in the F1 subunit of the fusion protein. Upon oral administration, BMS-433771 was able to reduce viral titers in the lungs of mice infected with RSV. This new class of orally active RSV fusion inhibitors offers potential for clinical development.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC321540PMC
http://dx.doi.org/10.1128/AAC.48.2.413-422.2004DOI Listing

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