AI Article Synopsis
- A new series of effective and selective dipeptidyl caspase-3 inhibitors has been discovered.
- The discovery involved a step-by-step process utilizing techniques like combinatorial chemistry, parallel synthesis, and molecular modeling.
- The report will focus on how structural biology played a role in understanding the inhibitors’ effectiveness.
Article Abstract
The discovery of a series of potent, selective and reversible dipeptidyl caspase-3 inhibitors are reported. The iterative discovery process of using combinatorial chemistry, parallel synthesis, moleculare modelling and structural biology will be discussed.
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| http://dx.doi.org/10.1016/j.bmcl.2003.10.064 | DOI Listing |
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