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Retinoblastoma and beyond: pediatric orbital mass lesions.
Neuroradiology
December 2024
Department of Neuroradiology, Istituto Giannina Gaslini, Genoa, Italy.
Various space occupying lesions can arise in the orbit, ranging from developmental anomalies to malignancies, and many of the diseases occurring in children are different from the pathologies in the adult population. As the clinical presentation is frequently nonspecific, radiologic evaluation is essential for lesion detection and characterization as well as patient management. While orbital masses may in some cases involve multiple compartments, a simple compartmental approach is the key for the diagnosis on imaging studies, and MRI is the modality of choice.
View Article and Find Full Text PDFChronic myelomonocytic leukaemia causing orbital inflammation.
BMJ Case Rep
October 2024
Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland.
Article Synopsis
- The case study describes a patient with chronic myelomonocytic leukemia (CMML) who experienced sudden orbital inflammation, leading to significant eye issues like bulging (proptosis) and increased eye pressure.
- Despite initial treatments not working, the patient's condition improved quickly after starting intravenous steroids.
- The case highlights that CMML, although rare, can cause orbital inflammation and suggests it should be considered in patients with ongoing high levels of monocytes.
Factors influencing the outcomes of trabeculectomy, conventional canaloplasty, and mitomycin C augmented canaloplasty.
Graefes Arch Clin Exp Ophthalmol
October 2024
Department of Ophthalmology, Faculty of Medicine and University Hospital of Cologne, 50937, Cologne, Germany.
Purpose: To compare the efficacy, safety, and factors influencing the outcomes of trabeculectomy (TE), conventional canaloplasty (cCP), and mitomycin C augmented canaloplasty (mCP) in glaucoma patients.
Methods: Intraocular pressure (IOP), the number of IOP-lowering eye drops, and surgery-related complications were evaluated at baseline and through 18 months postoperatively. Correlations between patients' demographic data, ophthalmic and non-ophthalmic conditions, outcomes and complications were evaluated.
Invasive Candidiasis in Pediatric Hematologic Malignancy: Increased Risk of Dissemination With Candida tropicalis.
Pediatr Infect Dis J
January 2025
From the Department of Pediatrics, Section of Pediatric Infectious Diseases, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas.
Article Synopsis
- Candida species are a leading cause of invasive fungal diseases, particularly affecting children with blood cancers; the study found that non-albicans Candida (NAC), especially C. tropicalis, are linked to worse outcomes in these patients.* -
- Researchers reviewed data from 53 patients over a decade and discovered a high incidence rate of invasive candidiasis (IC) and a significant link between C. tropicalis infections and dissemination to various organs, including the eyes and skin.* -
- The study highlights the importance of eye examinations in patients with IC, revealing that a notable percentage showed evidence of intraocular candidiasis, and emphasizes the need for further research to refine screening strategies for at-risk patients.*
Primary Intraocular Lymphoma: Rad-Path and Ophthalmologic Correlation.
AJNR Am J Neuroradiol
September 2024
(1) University of Rochester, School of Medicine and Dentistry, Rochester NY 14620 (D.S), (2) Eastern Virginia Medical School, Norfolk, VA 23507 (J.P), (3) University of Connecticut, School of Medicine, Farmington, CT 06032 (ER), (4) Department of Radiology, Mayo Clinic, Jacksonville, 4500 San Pablo Road, Jacksonville, FL 55902, USA (P.V, A.A, N.S), (5) Department of Radiology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55902, USA (G.B), (6) Department of Pathology, Mayo Clinic, Jacksonville, 4500 San Pablo Road, Jacksonville, FL 55902, USA (S.W).
Primary intraocular lymphoma (PIOL) is a rare form of primary central nervous system lymphoma that poses diagnostic challenges due to its nonspecific clinical features and complex imaging characteristics. This paper presents a focus case and two companion cases, highlighting the complexities in identifying and treating PIOL. In the focus case, A 66-year-old male experienced gradual painless vision loss with choroidal thickening on funduscopic exam and subsequent follow-up MRI.
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