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Intra-abdominal sepsis attenuates local inflammation-mediated increases in microvascular permeability at remote sites in mice in vivo. | LitMetric

AI Article Synopsis

  • - The study investigates how systemic inflammation, like sepsis, impacts leukocyte interactions with blood vessels, particularly looking at microvascular leakage at sites distant from the infection.
  • - Using a mouse model, the researchers observed that systemic infections reduced both leukocyte attachment to blood vessel walls and permeability in response to local infections.
  • - The findings indicate that intra-abdominal sepsis can actually lessen the damage caused by local inflammation by limiting the adherence of leukocytes to the endothelium, suggesting a complex relationship between local and systemic inflammatory responses.

Article Abstract

Background: Given that leukocyte delivery to remote sites is diminished in states of systemic inflammation, such as sepsis, and activated leukocytes may be responsible for endothelial injury leading to vascular leakage, we hypothesized that intra-abdominal sepsis would diminish microvascular leakage at remote sites by altering leukocyte-endothelial interactions.

Methods: Using a murine intravital microscopy model, we examined leukocyte-endothelial interactions and vascular leakage at a peripheral site in the presence of local and/or systemic inflammation. Forty mice were randomized to 1 of 4 study groups: local infection (orchitis), systemic infection (intra-abdominal sepsis by cecal ligation and puncture), local and systemic infection, and control. Postcapillary venules of the cremaster muscle were examined by bright light and fluorescence intravital microscopy. Microvascular leakage was determined after intravenous administration of fluorescent albumin.

Results: Systemic infection attenuated the increases in both leukocyte adherence and local infection-induced microvascular permeability. Neutrophil cell-surface expression of L-selectin, as determined by flow cytometry, diminished with both local and systemic infection, whereas expression of CD11b increased with systemic, but not local, infection.

Conclusions: These data suggest that systemic (intra-abdominal) sepsis diminishes local inflammation-mediated vascular leakage by attenuating leukocyte adherence.

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Source
http://dx.doi.org/10.1016/j.surg.2003.08.009DOI Listing

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