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Summary of the National Advisory Committee on Immunization (NACI) Statement-Updated guidance on Imvamune in the context of a routine immunization program.
Can Commun Dis Rep
January 2025
Department of Medicine, University of Alberta, Edmonton, AB.
Background: Mpox is a viral illness related to smallpox. It can cause flu-like symptoms and a rash, and in severe cases, can lead to hospitalization or death. The Imvamune® vaccine offers protection against mpox.
View Article and Find Full Text PDFEffectiveness of Tecovirimat in Mpox Cases: A Systematic Review of Current Evidence.
J Med Virol
December 2024
SR Sanjeevani Hospital, Kalyanpur, Siraha, Nepal.
Mpox, formerly known as monkeypox, has re-emerged as a significant global health concern, particularly during the widespread outbreak of 2022. As an orthopoxvirus related to the eradicated smallpox virus, mpox has been primarily managed with smallpox vaccines and treatments, including the antiviral agent Tecovirimat. This systematic review aims to evaluate the effectiveness and safety of Tecovirimat in treating mpox, focusing on its use during the 2022 outbreak, especially among high-risk populations, including men who have sex with men and people living with HIV.
View Article and Find Full Text PDF[Smallpox vaccination in the Brazilian province of Paraná, 1853-1863].
Hist Cienc Saude Manguinhos
December 2024
Doutor, História Social/Universidade Federal do Paraná. Curitiba - PR - Brasil
This study reflects on the efforts to disseminate and administer the smallpox vaccine in the Brazilian province of Paraná between 1853 and 1863, taking a circulation-based perspective. Chronologically, the first milestone is the founding of Paraná and the second is the drafting of the first regulations for vaccination in the province. This research draws on the assumptions of translocal microhistory and the theoretical conceptions expounded by Kapil Raj and Fa-ti Fan.
View Article and Find Full Text PDFConstant Desbordes Painting of Jean-Louis Alibert Administering the Smallpox Vaccine ("La Vaccine"): An Historic Vaccination or Artistic Imagination?
Clin Dermatol
December 2024
Jefferson Center for International Dermatology and Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
In 1822, France's Ministry of the Interior, concerned about dropping vaccination rates among the population, commissioned the French artist Constant Joseph Desbordes (1761-1828) to create an artwork that would educate the public about the benefits of the smallpox vaccine. The Painting that resulted is entitled: "La Vaccine" ("The Cowpox Inoculation") and a copy of it is entitled "La Vaccine au Chateau de Liancourt" ("Performing the Vaccination against Smallpox in the Chateau of Liancourt"). The highlight of the painting is its central figure, one of France's most distinguished physicians, Jean-Louis Alibert (1768-1837) performing, in dramatic fashion, the arm to arm method of smallpox vaccination that was common at that time.
View Article and Find Full Text PDFPlaque reduction neutralization test for smallpox vaccines: Laboratory optimization and validation method for immunogenicity assessment.
J Immunol Methods
January 2025
Division of Infectious Disease Vaccine Research, Center for Vaccine Research, National Institute of Infectious Diseases, National Institute of Health, CheongJu, Chungbuk, Republic of Korea. Electronic address:
The eradication of smallpox, a historic triumph in global public health, was accomplished without a complete conception of the mechanisms underlying vaccine-induced protection. Contemporary concerns regarding potential bioterrorism threats and the possibility of smallpox reemergence have spurred research efforts toward developing third-generation vaccines capable of effectively neutralizing the variola virus. Clinical trials for a third-generation smallpox vaccine (KVAC103) are underway to obtain licensure.
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