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Light chain cast nephropathy caused by plasmablastic lymphoma of the bladder.
Clin Nephrol Case Stud
July 2021
Department of Medicine, Division of Nephrology, Lehigh Valley Health Network, Allentown, PA.
Introduction: Plasmablastic lymphoma (PBL) is a rare form of B-cell lymphoma typically seen in patients with underlying immunosuppression such as HIV, autoimmune disease, and organ transplantation. PBL in HIV-positive patients usually originates from the gastrointestinal tract, with a predilection for the oral cavity. Bladder involvement by PBL is exceedingly rare, and cast nephropathy due to κ light chain-secreting PBL has not been reported previously.
View Article and Find Full Text PDFGiant forehead plasmacytoma as a growing lump in a patient with multiple myeloma.
Radiol Case Rep
December 2020
Pathology division, Hospital Pablo Tobón Uribe, Medellín, Colombia.
Extramedullary plasmacytoma represents less than 5% of plasma cell malignancies, 85% corresponding to head and neck masses. Symptoms are related to compressive effects according to location, aesthetics issues and can be misleading associated with soft tissue disorders. In this case report, we discuss a 70-year-old woman who presented with a 3-month history of a growing painless forehead lump and confusion, for which she had an emergent simple head computed tomography scan.
View Article and Find Full Text PDFNephrotic syndrome after autologous hematopoietic stem cell transplantation: a case report.
Rom J Morphol Embryol
August 2018
Department of Urology, University of Medicine and Pharmacy of Craiova, Romania;
Nephrotic syndrome (NS) is a rare complication of hematopoietic cell transplantation (HCT) and is thought to represent a renal manifestation of chronic graft-versus-host disease (cGVHD). Glomerulopathies occur less often in recipients of autologous as compared to allogeneic HCT and, in this setting, renal pathology is less well characterized. This case report describes a 54-year-old man admitted for the evaluation of a nephrotic-range proteinuria.
View Article and Find Full Text PDFCrystalline podocytopathy and tubulopathy without overt glomerular proteinuria in a patient with multiple myeloma.
Kidney Res Clin Pract
December 2016
Department of Nephrology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Crystalline nephropathy is a rare yet well-known condition associated with multiple myeloma and other light chain-secreting disorders. Paraproteins that are resistant to proteolysis crystallize within proximal tubular cells and cause light-chain proximal tubulopathy, which presents clinically as Fanconi syndrome. Podocytes are rarely affected, and the crystalline inclusions within podocytes are typically precipitated, yielding significant glomerular proteinuria.
View Article and Find Full Text PDFA tale of the unexpected: Amyloidoma associated with intracerebral lymphoplasmacytic lymphoma.
J Neurol Sci
December 2015
Department of Neurology, Derriford Hospital, Plymouth, UK.
Amyloidoma is a rare cause for intracranial space-occupying lesions diagnosed on brain imaging. Histology of excised tissue usually reveals the presence of a discrete, λ-light chain secreting plasmacytoma adjacent to an amyloid mass comprising aggregated monoclonal immunoglobulin light chains. We described a patient with intracerebral amyloidoma associated with a localised lymphoplasmacytic lymphoma and no systemic paraproteinaemia, tumour or amyloid deposits.
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