The ongoing debate surrounding the surgical treatment of trochanteric hip fractures, particularly unstable fractures, has led to continuous changes in the design of well-established implants and to the development of new ones. The goal of this paper was to use a finite element simulation to compare the biomechanical behaviour of two intramedullary implants most often used at the University Hospital of Zaragoza: the standard Gamma nail (Howmedica) and the proximal femoral nail (PFN, Stratec). The main focus was on the displacements of the fracture focus and the stress distributions along the femur and the implant. Both nails produced an important redistribution of stress in the bone tissue, but the redistribution of peak stress was higher for the Gamma nail. On the other hand, with PFN there were smaller displacements at the fracture site. Finally, under the same workload, the Gamma nail supported higher stresses than the PFN.
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http://dx.doi.org/10.1016/s0020-1383(03)00076-7 | DOI Listing |
J Bone Joint Surg Am
January 2025
Surgical Outcomes and Analysis Department, Kaiser Permanente, San Diego, California.
Background: Although the majority of intertrochanteric femoral fractures in the United States are now treated with cephalomedullary nailing, it remains uncertain whether differences in clinical performance by nail type exist. The purpose of this study was to compare the aseptic revision rates associated with the 3 most commonly utilized cephalomedullary nails in the United States today: the Gamma nail (Stryker), the INTERTAN (Smith+Nephew), and the Trochanteric Fixation Nail/Trochanteric Fixation Nail Advanced (TFN/TFNA; DePuy Synthes).
Methods: Using an integrated health-care system's hip fracture registry, patients ≥60 years of age who were treated with 1 of these 3 commonly used cephalomedullary nail devices were identified.
Objectives: To compare lag-screw slide and revision surgery rate between two generations of the Stryker Gamma cephalomedullary nail (Stryker, Kalamazoo, MI).
Methods: Design: Retrospective chart review.
Setting: Single academic, Level-1 Trauma Center.
J Invest Dermatol
December 2024
Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany; Department of Dermatology, Ludwig-Maximilians University Hospital, Munich, Germany. Electronic address:
Lichen planus (LP) is a chronic inflammatory disease (ISD) affecting skin, mucosa, nail, and hair. Previous studies demonstrated a pivotal role of type 1 immunity in LP, as infiltrating T cells trigger apoptosis and necroptosis in the epidermis. In this study, we investigated the role of DAPK1 in LP with special focus on its role in mediating cell death and inflammation.
View Article and Find Full Text PDFPharmacol Biochem Behav
December 2024
Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, RS, Brazil. Electronic address:
Schizophrenia is a mental disorder characterized by positive, negative, and cognitive symptoms which is treated with antipsychotics. However, these drugs present several side effects and, some schizophrenia symptoms, like cognitive, are difficult to treat. The peroxisome proliferator-activated receptors-gamma (PPAR-γ) are expressed in dopaminergic neurons of the midbrain participating in the modulation of dopamine-mediated behavior .
View Article and Find Full Text PDFCurr Health Sci J
September 2024
Physiology Sciences Department, University of Medicine and Pharmacy, of Craiova, Romania.
Introduction: The aging population is associated with increased osteoporosis and risk of hip fractures. Cognitive decline has recorded exponential increases in the last decades, with the rise in life expectancy.
Material And Methods: We conducted a prospective study on 65 patients over 65 years old associated with dementia and hip fractures.
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