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A Review on Circular RNA Translation and Its Implications in Disease.
Methods Mol Biol
December 2024
University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China.
The mRNA vaccine has emerged as a powerful tool against viral infection during the coronavirus disease 2019 (COVID-19) pandemic. In the post-COVID-19 era, the applications of mRNA-based therapy continue to expand and evolve. Circular RNA (circRNA), long assumed to be a noncoding RNA, has been proven to be translatable and subsequently developed as a next-generation mRNA modality due to its higher stability and wider therapeutic window.
View Article and Find Full Text PDFTranslational PK-PD model for in vivo CAR-T-cell therapy delivered using CAR mRNA-loaded polymeric nanoparticle vector.
Clin Transl Sci
December 2024
Oncology Cell Therapy and Therapeutic Area Unit, Cell Therapy Clinical Pharmacology and Modeling, Precision and Translational Medicine, Takeda Pharmaceuticals, Cambridge, Massachusetts, USA.
Autologous chimeric antigen receptor (CAR) T-cell therapy has demonstrated remarkable response rates, yet its widespread implementation is hindered by logistical, financial, and physical constraints. Additionally, challenges such as poor persistence and allorejection are associated with allogeneic cell therapies. An innovative approach involves in vivo transduction of endogenous T-cells through the administration of CAR mRNA encapsulated in polymeric nanoparticles (NPs), resulting in transient CAR surface expression on circulating T-cells.
View Article and Find Full Text PDFCross-talk between cuproptosis and ferroptosis to identify immune landscape in cervical cancer for mRNA vaccines development.
Eur J Med Res
December 2024
Department of Oncology, The Second Xiangya Hospital, Central South University, No. 72 Xiangya Road, Changsha, 410000, Hunan, China.
Messenger RNA (mRNA)-based vaccines present a promising avenue for cancer immunotherapy; however, their application in cervical cancer remains unexplored. This study investigated the interplay between the regulated cell death pathways of cuproptosis and ferroptosis to advance the development of mRNA vaccines for cervical cancer. We identified key cuproptosis-related and ferroptosis-related genes (CFRGs) from public mRNA profiles and determined their prognostic significance, mutation frequencies, and effect on the immune landscape.
View Article and Find Full Text PDFExploring the landscape of Lipid Nanoparticles (LNPs): A comprehensive review of LNPs types and biological sources of lipids.
Int J Pharm X
December 2024
Nanomedicine Department, King Abdullah International Medical Research Center, King Abdulaziz Medical City, Riyadh 11426, Saudi Arabia.
Lipid nanoparticles (LNPs) have emerged as promising carriers for delivering therapeutic agents, including mRNA-based immunotherapies, in various biomedical applications. The use of LNPs allows for efficient delivery of drugs, resulting in enhanced targeted delivery to specific tissues or cells. These LNPs can be categorized into several types, including liposomes, solid lipid nanoparticles, nanostructured lipid carriers, and lipid-polymer hybrid nanoparticles.
View Article and Find Full Text PDFmRNA-encoded fluorescent proteins enable superior organelle labeling for live cell imaging.
FASEB J
December 2024
Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Live cell labeling of various organelles is of great demand in the research field of cell biology. However, current approaches often lack an optimal balance between efficiency and versatility. We took advantage of chemical modified mRNA to express various organelle located fluorescent proteins.
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