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Novel multiple Z-score models for detection of coronary artery dilation: application in Kawasaki disease.
Pediatr Rheumatol Online J
December 2024
Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Background: This study aims to develop Z-Score models to normalize measurements of three coronary arteries and enhance the diagnosis of Kawasaki disease (KD) in children from newborns to 10 years old. Developing a reliable Z-Score model is challenging, as some existing models fail the normality test. Overcoming these challenges is crucial for improving KD diagnosis.
View Article and Find Full Text PDFOutcomes of loop ileostomy after rectal resection for cancer: A prospective observational multicenter snapshot study from Multidisciplinary Italian Study group for STOmas (MISSTO).
Tech Coloproctol
December 2024
Unit of General Surgery, Santa Maria Della Misericordia Hospital, Rovigo, Italy.
Background: Diverting ileostomy is a common procedure in rectal cancer surgery, but it is sometimes associated with a nonnegligible rate of complications. The primary aim of this study was to analyze the incidence and types of stoma-related complications for ileostomy creation after rectal cancer resection. The secondary aims were to report the indications, the technical details, and the efficacy of stoma care provided by ostomy nurses.
View Article and Find Full Text PDFRisk factors and risk prediction model for mucocutaneous separation in enterostomy patients: A single center experience.
World J Clin Cases
November 2024
Department of Operation Room, Zhejiang Chinese Medical University, Lishui Central Hospital, 289 Kuocang Road, Liandu District, Lishui 323000, Zhejiang Province, China.
Article Synopsis
- Mucocutaneous separation (MCS) is a common complication after enterostomy surgeries, with a 22.4% incidence rate in a recent study, highlighting the importance of identifying risk factors to prevent it.
- The study involved 492 patients and developed a predictive model for MCS based on factors such as suture dislodgement, serum albumin levels, body mass index (BMI), and incision infections, among others.
- The resulting model demonstrated strong predictive accuracy with an area under the curve of 0.827, indicating it can effectively help clinicians identify at-risk patients post-surgery.
The mechanism underlying B-cell developmental dysfunction in Kawasaki disease based on single-cell transcriptomic sequencing.
Front Immunol
November 2024
Department of Cardiology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Background: Kawasaki disease (KD) is an acute systemic vasculitis that can lead to acquired heart disease in children mostly from in developed countries. The previous research showed that B cells in KD patients underwent a profound change in both the cell numbers and types after intravenous immunoglobulin (IVIG) therapy.
Methods: We performed the single-cell RNA-sequencing for the peripheral blood mononuclear cells (PBMCs) from three febrile patients and three KD patients to investigate the possible mechanism underlying B cell developmental dysfunction in KD.
Role of neutrophil-lymphocyte ratio as a prognostic marker in SJS/TEN patients.
Arch Dermatol Res
August 2024
Department of Dermatology, Venereology and Leprosy, Father Muller Medical College, Mangalore, India.
Article Synopsis
- Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious skin reactions mainly triggered by drugs, and SCORTEN is used to predict their severity and mortality risk.
- A recent study sought to determine if the neutrophil-lymphocyte ratio (NLR) could serve as a prognostic marker for SJS/TEN by analyzing patient data over four years from a hospital.
- Although a weak positive correlation was found between NLR and SCORTEN, it wasn’t statistically significant, suggesting that while NLR indicates systemic inflammation, its effectiveness in predicting disease severity needs further research with more patients.
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