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Bioinspired Electrostatic Capture-and-Release System for Precise Microdroplet Manipulation.
Adv Mater
January 2025
Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 100083, China.
The application of physical fields is crucial for droplet generation and manipulation, underpinning technologies like printing, microfluidic biochips, drug delivery, and flexible sensors. Despite advancements, precise micro/nanoscale droplet generation and accurate microfluidic reactions remain challenging. Inspired by the liquid ejection mechanisms in microscopic organisms, an electrostatic manipulator for the precise capture, emission, and transport of microdroplets is proposed.
View Article and Find Full Text PDFCirculating Tumor Cells Culture: Methods, Challenges, and Clinical Applications.
Small Methods
December 2024
Department of Precision Diagnostic and Therapeutic Technology, City University of Hong Kong Shenzhen Futian Research Institute, Shenzhen, 518057, China.
Circulating tumor cells (CTCs) play a pivotal role in cancer metastasis and hold considerable potential for clinical diagnosis, therapeutic monitoring, and prognostic evaluation. Nevertheless, the limited quantity of CTCs in liquid biopsy samples poses challenges for comprehensive downstream analysis. In vitro culture of CTCs can effectively address the issue of insufficient CTC numbers.
View Article and Find Full Text PDFConcurrent Detection of Protein and miRNA at the Single Extracellular Vesicle Level Using a Digital Dual CRISPR-Cas Assay.
ACS Nano
December 2024
School of Biomedical Engineering, Tsinghua University, Beijing 100084, China.
The simultaneous detection of proteins and microRNA (miRNA) at the single extracellular vesicle (EV) level shows great promise for precise disease profiling, owing to the heterogeneity and scarcity of tumor-derived EVs. However, a highly reliable method for multiple-target analysis of single EVs remains to be developed. In this study, a igital ual CRISPR-Cas-powered ingle V valuation () system was proposed to enable the concurrent detection of surface protein and inner miRNA of EVs at the single-molecule level.
View Article and Find Full Text PDFChronic wound management: a liquid diode-based smart bandage with ultrasensitive pH sensing ability.
Microsyst Nanoeng
December 2024
School of Biomedical Engineering, Tsinghua University, Beijing, 100084, China.
Chronic wounds, which require prolonged healing periods, pose significant impacts on individuals with diabetes, vascular diseases, and high blood pressure. Simultaneous drainage and monitoring of wound exudate are vital for advanced wound management. However, recently reported smart dressings either lack integration of wound cleaning and monitoring functions or fail to achieve dynamic in situ monitoring of wound status, which hinders their ability to meet the demands of wound care.
View Article and Find Full Text PDFBaricitinib-loaded EVs promote alopecia areata mouse hair regrowth by reducing JAK-STAT-mediated inflammation and promoting hair follicle regeneration.
Drug Discov Ther
January 2025
Department of Dermatology, Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.
Alopecia areata (AA) is a common and recurrent type of hair loss. Despite oral administration of baricitinib exerts a good effect on refractory AA, the long-term administration of baricitinib carries significant side effects, poor compliance, and the efficacy is difficult to maintain after drug withdrawal. Therefore, the exploration of a safe and effective local administration of baricitinib to treat AA is of great clinical importance.
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