AI Article Synopsis
- The study analyzed the antimicrobial effects of the peptide PsVP-10 on 67 resistant Enterococcus faecalis strains from clinical sources.
- Results indicated that these strains exhibited high Minimum Inhibitory Concentrations (MICs) to common antibiotics, demonstrating significant multidrug resistance.
- PsVP-10 showed lower MICs against both resistant and susceptible strains, suggesting its potential as a new antimicrobial agent to combat resistant E. faecalis.
Article Abstract
Objective: To analyse the antimicrobial activity of the peptide PsVP-10 against 67 resistant Enterococcus faecalis strains isolated from clinical samples.
Methods: The qualitative disc diffusion method and MIC determinations were used.
Results: The presence of several multidrug-resistant phenotypes of E. faecalis was demonstrated, in which there were high MICs to chloramphenicol, tetracycline, vancomycin, cefaloridine, ampicillin and gentamicin. In comparison, the peptide PsVP-10 showed lower MICs against all the multidrug-resistant and susceptible E. faecalis.
Conclusions: There is an urgent need for the development of novel antimicrobial agents against the highly resistant E. faecalis. The present study shows that the peptide PsVP-10 might make a contribution to the solution of this serious problem.
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| http://dx.doi.org/10.1093/jac/dkh067 | DOI Listing |
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