AI Article Synopsis
Article Abstract
Objective: To evaluate the effect of serum/cerebrospinal fluid (CSF) ratio of human chorionic gonadotropin (hCG) in detecting brain metastases of gestational trophoblast tumor and the significance of prophylactic intrathecal therapy.
Methods: Clinical information of 44 patients with brain metastases (stage IV) and 29 patients with lung metastases (stage III) of gestational trophoblast tumor who were admitted to our hospital between 1986 to 2001 were retrospectively analyzed by case control study. The variability of the ratio and the relationship between brain metastases was investigated, together with the effect of prophylactic intrathecal therapy.
Results: Serum/CSF hCG ratio in patients with brain metastases declined with time. The ratio before chemotherapy was in relevant with the size of the lesion which were less than 60 in advanced stages and more than 60 in early stages. Patients of stage III with prophylactic intrathecal therapy did not progress to stage IV.
Conclusions: Serum/CSF hCG ratio before chemotherapy could reflect the encephalic tumor load which had reference value in diagnosis and prognosis and prophylactic intrathecal therapy played an important role in preventing brain metastasis.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Efficacy of GABA aminotransferase inactivator OV329 in models of neuropathic and inflammatory pain without tolerance or addiction.
Proc Natl Acad Sci U S A
January 2025
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405.
Dysregulation of GABAergic inhibition is associated with pathological pain. Consequently, enhancement of GABAergic transmission represents a potential analgesic strategy. However, therapeutic potential of current GABA agonists and modulators is limited by unwanted side effects.
View Article and Find Full Text PDFEffect of crystalloid solution co-loading infusion rate on the dose requirements of prophylactic phenylephrine for preventing hypotension following combined spinal-epidural anesthesia for cesarean delivery.
BMC Pregnancy Childbirth
November 2024
Department of Anesthesia, Jiaxing University Affiliated Women and Children Hospital, No. 2468 East Zhonghuang Road, Jiaxing city, 314050, China.
Background: Intravenous fluid administration and prophylactic vasopressor infusion are the primary methods for preventing spinal anesthesia-induced hypotension during cesarean delivery. However, evidence regarding the impact of different volumes of crystalloid solution on the phenylephrine infusion dosage for preventing this hypotension remains inconclusive. This study aimed to determine the effect of two IV fluid infusion rates (10 or 20 mL/kg/h) on phenylephrine requirement for preventing spinal anesthesia-induced hypotension.
View Article and Find Full Text PDFPaediatric Acute Lymphoblastic Leukaemia: A Narrative Review of Current Knowledge and Advancements.
Curr Oncol Rep
December 2024
Department of Basic and Clinical Sciences, University of Nicosia Medical School, 21 Ilia Papakyriakou, 2414 Engomi, P.O. Box 24005, CY-1700, Nicosia, Cyprus.
Article Synopsis
- This review highlights advancements in the diagnosis and treatment of pediatric acute lymphoblastic leukemia (ALL), noting recent progress in achieving a 90% survival rate and the need for accurate diagnostic methods that consider genetic and environmental factors.
- It discusses the treatment process, which consists of three phases of chemotherapy and mentions emerging therapies like CAR T-cell therapy and stem cell transplants for high-risk cases, while emphasizing the importance of ongoing clinical trials.
- Lastly, the review points out disparities in global healthcare access that affect timely diagnosis and treatment, and stresses the need for more research on prevention strategies and improvements in healthcare systems to enhance patient outcomes.
Morphine-induced hyperalgesia impacts small extracellular vesicle miRNA composition and function.
bioRxiv
October 2024
Department of Pharmacology & Physiology, Drexel University College of Medicine, 245 North 15th Street, Philadelphia, PA, USA.
Morphine and other synthetic opioids are widely prescribed to treat pain. Prolonged morphine exposure can paradoxically enhance pain sensitivity in humans and nociceptive behavior in rodents. To better understand the molecular mechanisms underlying opioid-induced hyperalgesia, we investigated changes in miRNA composition of small extracellular vesicles (sEVs) from the serum of mice after a morphine treatment paradigm that induces hyperalgesia.
View Article and Find Full Text PDFProphylactic Cranial Irradiation prior to HCT for Acute Lymphoblastic Leukemia: To Boost or Not To Boost.
Clin Hematol Int
October 2024
Department of Pediatrics, Pediatric Bone Marrow Transplantation and Cellular Therapy Program King Hussein Cancer Center.
Article Synopsis
- * A study reviewed 166 patient records, focusing on 143 without prior central nervous system (CNS) involvement, and analyzed the outcomes of those who received TBI with or without CRB.
- * Results showed no significant differences in relapse rates or survival between patients with and without CRB, indicating that adding CRB may not provide extra benefits in preventing relapses after transplantation.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!