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Schisandrin B exerts anti-colorectal cancer effect through CXCL2/ERK/DUSP11 signaling pathway.
Cancer Cell Int
March 2025
Department of Pharmacy, Second Affiliated Hospital of Naval Medical University, No. 415, Fengyang Road, Shanghai, 200003, P. R. China.
Background: Schisandrin B (Sch B) is an active component in Schisandra chinensis exerting anti-cancer effect, but the mechanism is obscure. This study was designed to explore the mechanism of Sch B against colorectal cancer (CRC).
Method: Apparent experiments including cell proliferation, transwell, colony formation, etc.
Ameliorative and protective effects of coenzyme Q10 against natural and chemical toxicity: a narrative review.
Naunyn Schmiedebergs Arch Pharmacol
March 2025
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Coenzyme Q10 (CoQ10) or ubiquinone is the most known dietary and nutritional supplementation, which has various functions in the body such as involvement in adenosine triphosphate production, modulation of gene expression, antioxidant, and anti-inflammatory effects. It has been indicated that it is useful against cardiotoxicity, hepatotoxicity, neurotoxicity, nephrotoxicity, and so on, which are induced by various toxicants. In this review, we selected articles that include the protective effects of CoQ10 against the toxicity of various chemical and natural compounds including pharmaceuticals, metals, pesticides, etc.
View Article and Find Full Text PDFBeneficial Antioxidant Effects of Coenzyme Q10 in In Vitro and In Vivo Models of CDKL5 Deficiency Disorder.
Int J Mol Sci
February 2025
Department of Biomedical and Neuromotor Sciences, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy.
deficiency disorder (CDD), a developmental encephalopathy caused by mutations in the cyclin-dependent kinase-like 5 () gene, is characterized by a complex and severe clinical picture, including early-onset epilepsy and cognitive, motor, visual, and gastrointestinal disturbances. This disease still lacks a medical treatment to mitigate, or reverse, its course and improve the patient's quality of life. Although CDD is primarily a genetic brain disorder, some evidence indicates systemic abnormalities, such as the presence of a redox imbalance in the plasma and skin fibroblasts from CDD patients and in the cardiac myocytes of a mouse model of CDD.
View Article and Find Full Text PDFgen. nov., sp. nov., a novel halophilic bacterium isolated from tidal flat sediment.
Int J Syst Evol Microbiol
March 2025
Department of Integrative Biotechnology, Sungkyunkwan University, Natural Science Campus, 2066 Seobu-ro, Jangan-gu, Suwon-si, Gyeonggi-do 16419, Republic of Korea.
A novel bacterial strain, MJW-29, was isolated from tidal flat sediment in Gochang, Republic of Korea. The isolate is Gram-stain-negative, facultatively anaerobic, gliding motile and short rods. The strain MJW-29 is oxidase and catalase positive.
View Article and Find Full Text PDFThe Impact of Coenzyme Q10 on Cognitive Dysfunction, Antioxidant Defense, Cholinergic Activity, and Hippocampal Neuronal Damage in Monosodium Glutamate-Induced Obesity.
Iran J Pharm Res
January 2025
Department of Biology, Kazeroon Branch, Islamic Azad University, Kazeroon, Iran.
Background: Obesity, a rising global health issue, is linked to numerous disorders, including cognitive impairment.
Objectives: This study investigates the effects of coenzyme Q10 (Co-Q10) on cognitive performance, antioxidant defense, cholinergic activity, and hippocampal neuron damage in rats rendered obese by monosodium glutamate (MSG) exposure.
Methods: Forty-eight neonatal male Wistar rats were randomly assigned to one of four groups: Control, MSG, MSG + Q10-10, and MSG + Q10-20.
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