The main contributions of a Romanian team, headed by I. Baciu, in the field of the control of erythropoiesis are presented. The role of the central nervous system in the regulation of erythrocytes production and the identification of chemoreceptors sensitive to hypoxia in the central nervous system are disclosed. The studies concerning the secretion and the effects of erythropoietin are also emphasized. The paper provided references to the recent data concerning the structure of erythropoietin, the membrane receptors, the metabolism and the practical applications of the hormone.
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Our knowledge of which bone marrow cells affect red cell production is still incomplete. To explore the role of osteocytes in the process we performed bulk RNAseq of osteocytes isolated from control and phlebotomized mice. The top-upregulated gene following phlebotomy was , erythroferrone ( ).
View Article and Find Full Text PDFJ Clin Med
January 2025
Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, 08036 Barcelona, Spain.
: High-volume online hemodiafiltration (OL-HDF) has proven to be the most efficient dialysis modality and to offer better clinical outcomes in patients on hemodialysis. Longer and more frequent dialysis sessions have demonstrated clinical and survival benefits. : A single-center observational study of the first one hundred patients on nocturnal every-other-day OL-HDF was conducted with the aim of reporting the experience with this treatment schedule and evaluating analytical and clinical outcomes as well as the patient and technique survival.
View Article and Find Full Text PDFEnviron Sci Technol
January 2025
Department of Occupational and Environmental Health, School of Public Health, Qingdao University, Qingdao 266071, China.
Tris(2-chloroethyl) phosphate (TCEP), a prevalent organophosphorus flame retardant, has been identified in various environmental matrices and human blood samples, provoking alarm regarding its hematological toxicity, a subject that has not been thoroughly investigated. Red blood cells (RBCs), or erythrocytes, are the predominant cell type in peripheral blood and are crucial for the maintenance of physiological health. This investigation employed oral gavage to examine the effects of TCEP exposure on erythrocyte counts in mice and to clarify the underlying mechanisms.
View Article and Find Full Text PDFJ Biol Chem
December 2024
University of Stuttgart, Institute of Biomedical Genetics, Department of Eukaryotic Genetics, Allmandring 31, 70569 Stuttgart, Germany. Electronic address:
Introduction: Anemia is a common global health problem, particularly in impoverished regions, with a high incidence rate. The condition is multifactorial, with iron deficiency being one of the most prevalent causes. Current treatment for anemia often relies on iron supplements or erythropoiesis-stimulating agents, although these therapies may show limited efficacy for some patients.
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