The control of erythropoiesis (Romanian contributions).

Rev Roum Physiol (1990)

Department of Physiology, University of Medicine and Pharmacy, Cluj-Napoca.

Published: February 1993

AI Article Synopsis

  • A Romanian research team led by I. Baciu has made significant contributions to understanding how the central nervous system regulates erythropoiesis, the production of red blood cells.
  • They identified chemoreceptors in the central nervous system that respond to low oxygen levels (hypoxia), which play a crucial role in this regulation.
  • The research also highlights the secretion of erythropoietin, its structure, metabolic pathways, and practical uses, underlining the hormone's importance in erythrocyte production.

Article Abstract

The main contributions of a Romanian team, headed by I. Baciu, in the field of the control of erythropoiesis are presented. The role of the central nervous system in the regulation of erythrocytes production and the identification of chemoreceptors sensitive to hypoxia in the central nervous system are disclosed. The studies concerning the secretion and the effects of erythropoietin are also emphasized. The paper provided references to the recent data concerning the structure of erythropoietin, the membrane receptors, the metabolism and the practical applications of the hormone.

Download full-text PDF

Source

Publication Analysis

Top Keywords

control erythropoiesis
8
central nervous
8
nervous system
8
erythropoiesis romanian
4
romanian contributions
4
contributions main
4
main contributions
4
contributions romanian
4
romanian team
4
team headed
4

Similar Publications

Our knowledge of which bone marrow cells affect red cell production is still incomplete. To explore the role of osteocytes in the process we performed bulk RNAseq of osteocytes isolated from control and phlebotomized mice. The top-upregulated gene following phlebotomy was , erythroferrone ( ).

View Article and Find Full Text PDF

: High-volume online hemodiafiltration (OL-HDF) has proven to be the most efficient dialysis modality and to offer better clinical outcomes in patients on hemodialysis. Longer and more frequent dialysis sessions have demonstrated clinical and survival benefits. : A single-center observational study of the first one hundred patients on nocturnal every-other-day OL-HDF was conducted with the aim of reporting the experience with this treatment schedule and evaluating analytical and clinical outcomes as well as the patient and technique survival.

View Article and Find Full Text PDF

Tris(2-chloroethyl) Phosphate Leads to Unbalanced Circulating Erythrocyte in Mice by Activating both Medullary and Extramedullary Erythropoiesis.

Environ Sci Technol

January 2025

Department of Occupational and Environmental Health, School of Public Health, Qingdao University, Qingdao 266071, China.

Tris(2-chloroethyl) phosphate (TCEP), a prevalent organophosphorus flame retardant, has been identified in various environmental matrices and human blood samples, provoking alarm regarding its hematological toxicity, a subject that has not been thoroughly investigated. Red blood cells (RBCs), or erythrocytes, are the predominant cell type in peripheral blood and are crucial for the maintenance of physiological health. This investigation employed oral gavage to examine the effects of TCEP exposure on erythrocyte counts in mice and to clarify the underlying mechanisms.

View Article and Find Full Text PDF

ID3 promotes erythroid differentiation and is repressed by a TAL1/PRMT6 complex.

J Biol Chem

December 2024

University of Stuttgart, Institute of Biomedical Genetics, Department of Eukaryotic Genetics, Allmandring 31, 70569 Stuttgart, Germany. Electronic address:

Article Synopsis
  • Erythropoiesis, the formation of red blood cells, is regulated by transcription factors like TAL1, which either activate or repress gene expression through epigenetic mechanisms.
  • TAL1 works with the cofactor PRMT6 to regulate the ID3 gene, essential for hematopoietic cell differentiation, by modifying histones and affecting ID3 expression.
  • Enhancing ID3 expression through manipulation may improve the in vitro differentiation of stem cells (hCD34+) into erythrocytes, providing insights into both normal and pathological red blood cell development.
View Article and Find Full Text PDF

Introduction: Anemia is a common global health problem, particularly in impoverished regions, with a high incidence rate. The condition is multifactorial, with iron deficiency being one of the most prevalent causes. Current treatment for anemia often relies on iron supplements or erythropoiesis-stimulating agents, although these therapies may show limited efficacy for some patients.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!