Eureka moments.

Pharos Alpha Omega Alpha Honor Med Soc

Published: February 2004

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Eureka moments can occur during all steps of discovery. Eighteen chemists and molecular scientists described their Eureka moments herein. Hints at fostering one's own Eureka moments are provided.

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Energy Associated With Dynamic Network Changes in Patients With Multiple Sclerosis and Cognitive Impairment.

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From the MS Center Amsterdam (T.A.A.B., M.v.D., V.R., L.D., Y.D.v.d.W., C.H.V., M.M.S.), Anatomy & Neurosciences, and MS Center Amsterdam (G.P., F.B.), Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (G.P., F.B.), University College London, United Kingdom; Departments of Advanced Biomedical Sciences and Electrical Engineering and Information Technology (G.P.), University of Naples "Federico II," Italy; MS Center Amsterdam (J.K.), Neurology, and MS Center Amsterdam (C.H.V.), Psychiatry, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc; Amsterdam Public Health (C.H.V.), Mental Health Program; and GGZ inGeest Mental Health Care (C.H.V.), Amsterdam, the Netherlands.

Article Synopsis
  • Patients with multiple sclerosis (MS) often face cognitive impairments due to structural disconnections in the brain, affecting how different regions communicate dynamically for normal cognitive function.* -
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Stem cell research is the product of cumulative, integrated effort between and within laboratories and disciplines. The many collaborative steps that lead to that special "Eureka moment", when something that has been a puzzle perhaps for years suddenly become clear, is among the greatest pleasures of a scientific career. In this essay, the serendipitous pathway from first acquaintance with pluripotent stem cells to advanced cardiovascular models that emerged from studying development and disease will be described.

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Many famous scientists have reported anecdotes where a new understanding occurred to them suddenly, in an unexpected flash. Do people generally experience such "Eureka" moments when learning science concepts? And if so, do these episodes truly vehicle sudden insights, or is this impression illusory? To address these questions, we developed a paradigm where participants were taught the mathematical concept of geodesic, which generalizes the common notion of straight line to straight trajectories drawn on curved surfaces. After studying lessons introducing this concept on the sphere, participants (N = 56) were tested on their understanding of geodesics on the sphere and on other surfaces.

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