AI Article Synopsis
- Researchers investigated the use of Langerin (CD207) as a reliable cell marker in diagnosing pulmonary Langerhans cell histiocytosis through bronchoalveolar lavage fluid samples.
- The study included comparisons with patients suffering from sarcoidosis and idiopathic pulmonary fibrosis to establish a control baseline.
- Findings showed a higher percentage of CD1a- and Langerin-positive cells in cases of pulmonary Langerhans cell histiocytosis, highlighting Langerin's potential for improving diagnostic methods.
Article Abstract
The diagnosis of pulmonary Langerhans cell histiocytosis might be refined by demonstrating reliability of a new cell marker, i.e., Langerin (CD207), used on bronchoalveolar lavage fluid. For this purpose, we collected material from patients with this disease and also with sarcoidosis and idiopathic pulmonary fibrosis as controls. In addition to the immunocytochemical detection of Langerin, we examined the expression profiles of CD1a and the macrophage tandem-repeat mannose receptor (CD206). To test accessibility of Langerin, a C-type lectin, for mannosides, we employed reverse lectin histochemistry using mannose-containing neoglycoproteins. The analysis revealed a significantly increased percentage of CD1a- and Langerin-positive cells in pulmonary Langerhans cell histiocytosis in comparison with both other studied diseases. No expression of the 175-kDa mannose-binding lectin (CD206) in Langerhans cells was observed. Evidently, binding sites on the cells were not accessible for the mannose-containing neoglycoligand. These results provide evidence for the usefulness of Langerin-directed immuno- and glycohistochemical monitoring of bronchoalveolar lavage fluid in the diagnosis of pulmonary Langerhans cell histiocytosis.
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| http://dx.doi.org/10.1007/s00428-003-0952-6 | DOI Listing |
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