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| http://dx.doi.org/10.1042/bj2881072 | DOI Listing |
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A simple HPLC-UV method for monitoring therapeutic adherence in pulmonary arterial hypertension.
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Pulmonary Circulation Centre, Department of Cardiac and Vascular Diseases, Jagiellonian University Medical College, Krakow, Poland; Department of Cardiac and Vascular Diseases, St. John Paul II Hospital, Krakow, Poland.
A considerable percentage of ineffective treatment in pulmonary arterial hypertension (PAH) may be related to subtherapeutic dosage or non-adherence. The aim of the study was to develop a simple analytical method suitable for plasma determination of selected drugs: riociguat (RIO), bosentan (BOS) and macitentan (MAC) administered to PAH patients. An isocratic HPLC-UV system (Spectra Physics - Shimadzu) with a manual injector (50 μL loop) was applied.
View Article and Find Full Text PDFDeconditioning in quiescent Crohn's Disease patients with heightened fatigue perception.
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Professor of Gastroenterology, Translational Medical Sciences, School of Medicine, Faculty of Medicine and Health Sciences, University of Nottingham; NIHR Nottingham Biomedical Research Centre, Nottingham.
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Background: Selecting the optimal dose for clinical development is especially problematic for drugs directed at CNS-specific targets. For drugs with a novel mechanism of action, these problems are often greater. We describe Xanamem's clinical pharmacology, including the approach to dose selection and proof-of-concept studies.
View Article and Find Full Text PDFQuantifying the growth mechanism of solid-state nanopores under high-voltage conditioning.
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The current study assesses several water-based PVT system thermal absorber configurations. The thermal absorber in PVT system plays a vital role in efficiency evaluation as it lowers PV temperature and collects heat energy. The current study aims to discover and analyze advanced thermal absorber design by comparing well-received spiral circular absorbers and non-cooled PV with proposed semi-circular thermal absorbers with varying flow configurations.
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