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Exp Neurol
December 2024
Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China; Spine Center, China International Neuroscience Institute (CHINA-INI), Beijing, China; Research Center of Spine and Spinal Cord, Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China; Lab of Spinal Cord Injury and Functional Reconstruction, China International Neuroscience Institute (CHINA-INI), Xuanwu Hospital, Capital Medical University, Beijing, China. Electronic address:
Syringomyelia is a neurological disease that is difficult to cure, and treatments often have limited effectiveness. In this study, a rat model of syringomyelia induced by epidural compression was used to investigate the factors that limit the prognosis of syringomyelia. After we treated syringomyelia rats with surgical decompression alone, MRI revealed that the syringomyelia rats did not show the expected therapeutic effect.
View Article and Find Full Text PDFBMC Neurol
November 2024
Department of Neurosurgery in Peking University First Hospital, No.8 Xishiku Street, Xicheng District, Beijing, 100034, China.
Background: Syringomyelia is a rare disease with diverse etiologies, and the syrinx is typically confined to certain segments of the spinal cord. Case of syringomyelia affecting the whole cord due to tethered cord is extremely rare, and the underlying pathophysiological mechanisms remain poorly understood.
Case Presentation: We described an 18-year-old male patient who presented with progressive weakness in both lower extremities and bladder dysfunction over the past four years.
Chiari Malformation Type I (CMI) is a prevalent neurosurgical condition characterized by the descent of cerebellar tonsils below the foramen magnum. Surgery, aimed at reducing symptomatology and syrinx size, presents risks, making intraoperative neuromonitoring (IONM) a potentially vital tool. Despite its widespread use in cervical spine surgery, the utility of IONM in CMI surgery remains controversial, with concerns over increased operative time, cost, restricted anesthetic techniques and tongue lacerations.
View Article and Find Full Text PDFCureus
July 2024
Trauma and Orthopaedics, University Hospitals Derby and Burton, Burton on Trent, GBR.
Charcot neuroarthropathy (CN) is a chronic degenerative disorder of bones and joints, mostly associated with diabetes mellitus and human immunodeficiency virus. CN of the upper limb is rare, with only 58 case reports identified on PubMed with the majority of cases being closely associated with syringomyelia. Very rarely, cervical spondylotic myelopathy (CSM) is associated with CN of the upper limb; with very few literature reporting this association.
View Article and Find Full Text PDFCureus
May 2024
Physical Medicine and Rehabilitation, International Center for Spinal Cord Injury, Kennedy Krieger Institute, Baltimore, USA.
Infratentorial superficial siderosis, characterized by hemosiderin deposition in the subpial layers of the brainstem, cerebellum, and spinal cord, is a rare progressive neurologic disorder. We present two cases of infratentorial superficial siderosis. Case 1 involves a 62-year-old female previously diagnosed with tethered cord syndrome and thoracic myelopathy, who, following 11 spinal surgeries, presented with worsening myelopathy, hearing loss, and cognitive impairment.
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