Quantitative study of the aortic atherosclerosis was performed in 587 males of the indigenous (IP) and in 149 males of non-indigenous population (NIP) at the age of 20 to 59 years in the city of Andizhan according to the WHO program. The course of atherosclerosis was more severe in NIP persons although at the age of up to 40 years the differences in the mean surface of atherosclerotic changes were lacking. The surface of lipid spots was similar in both groups or was somewhat lower in NIP, but these spots in NIP persons were thicker and contained more foam cells and more areas of diffuse lipid deposition. The rate of the surface increase of prominent lesions drastically increased in the 5th decade of life in both groups. The frequency of rhythmical structures in the aorta was the same in both groups; their incidence was higher in cases of pronounced atherosclerosis.
Download full-text PDF |
Source |
---|
Cardiovasc Diabetol
January 2025
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, No.2 Anzhen Road, Chaoyang District, 100029, Beijing, China.
Introduction: Bone marrow-derived mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) are widely used for therapeutic purposes in preclinical studies. However, their utility in treating diabetes-associated atherosclerosis remains largely unexplored. Here, we aimed to characterize BMSC-EV-mediated regulation of autophagy and macrophage polarization.
View Article and Find Full Text PDFJ Cardiovasc Surg (Torino)
February 2025
Department of Vascular Surgery, AZ Sint Blasius, Dendermonde, Belgium.
Background: Due to the heterogeneity of literature findings, stent type selection for the endovascular treatment of complex aorto-iliac occlusive disease remains challenging. The BELSTREAM study, a physician-initiated, prospective, multicenter, single-arm study, aims to report the safety and efficacy of the balloon expandable LifeStream Peripheral Stent Graft System (BD, Tempe, Arizona, USA) for the treatment of complex TASC C and D aorto-iliac artery lesions.
Methods: Seventy patients and 133 lesions were included at six Belgian institutions.
Cureus
January 2025
Internal Medicine, University of Florida College of Medicine, Gainesville, USA.
Fibromuscular dysplasia (FMD) is a non-atherosclerotic, non-inflammatory vascular disease of medium-sized arteries that causes abnormal cellular growth in arterial walls and most commonly affects young to middle-aged women (20-50 years of age). While FMD often involves the renal arteries, it can affect any arterial bed. FMD has a characteristic angiographic appearance of a "string of beads.
View Article and Find Full Text PDFComput Biol Med
January 2025
Department of Mechanical Engineering, Isfahan University of Technology, Isfahan, Iran. Electronic address:
Atherogenesis is prone in medium and large-sized vessels, such as the aorta and coronary arteries, where hemodynamic stress is critical. Low and oscillatory wall shear stress contributes significantly to endothelial dysfunction and inflammation. Murray's law minimizes energy expenditure in vascular networks and applies to small arteries.
View Article and Find Full Text PDFDrug Deliv Transl Res
January 2025
Center for Coronary Heart Disease, Department of Cardiology, National Center for Cardiovascular Diseases of China, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Rd, Beijing, 100037, China.
Atherosclerosis is one of the leading causes of ischemic cardiovascular disease worldwide. Recent studies indicated that vascular smooth muscle cells (VSMCs) play an indispensable role in the progression of atherosclerosis. Exosomes derived from mesenchymal stem cells (MSCs) have demonstrated promising clinical applications in the treatment of atherosclerosis.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!