AI Article Synopsis

  • 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone (MX) is a strong mutagen found in chlorinated drinking water, responsible for about one-third of its mutagenic effects.
  • Research on the impact of MX on mutations was conducted using medaka fish, comparing it with the known carcinogen methylazoxymethanol acetate (MAMAc).
  • While MAMAc exposure led to detectable mutations, MX exposure did not induce mutations in the medaka liver, indicating potential future studies will focus on other tissues like gills and skin to investigate MX's effects further.

Article Abstract

Mutagenicity assays with Salmonella have shown that 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone (MX), a drinking-water disinfection by-product, is a potent mutagen, accounting for about one-third of the mutagenic potency/potential of chlorinated drinking water. The ability of MX to induce mutations was investigated in the liver of medaka (Oryzias latipes), a small fish model, utilizing the cII transgenic medaka strain that allows detection of in vivo mutations. Methylazoxymethanol acetate (MAMAc), a carcinogen in medaka, served as a positive control. Fish were exposed to MX at 0, 1, 10, or 30 mg/L for 96 h, whereas the MAMAc exposures were for 2 h at 0, 0.1, 1, or 10 mg/L. Both exposures were conducted under static water conditions and with fasted medaka. Following exposure, fish were returned to regular culture conditions to allow mutation expression for 15 or 40 d for MX or for 15 or 32 d for MAMAc. Mutations were not induced in medaka exposed to MX for 96 h. However, a concentration- and time-dependent increase in mutations was observed from the livers of fish exposed to 1 and 10 mg/L MAMAc. In conclusion, mutation induction was not observed in the livers of cII medaka exposed to MX for 96 h; however, studies are planned to examine mutation induction in the gills and skin to explore the possibility that MX-induced DNA damage occurs primarily in the tissues of initial contact.

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http://dx.doi.org/10.1080/15287390490273587DOI Listing

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