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Use of Intravascular Micro-Axial Left Ventricular Assist Devices as a Bridging Strategy for Cardiogenic Shock: Mid-Term Outcomes.
J Clin Med
November 2024
Heart and Vascular Institute, Pennsylvania State Milton S Hershey Medical Center, Hershey, PA 17033, USA.
: Patients in cardiogenic shock (CS) may be successfully bridged using intravascular micro-axial left ventricular assist devices (M-LVADs) for recovery or determination of definitive therapy. : One hundred and seven CS patients implanted with M-LVADs from January 2020 to May 2024 were divided into four groups; group-1: 34 patients (transplant); group-2: 25 patients (LVAD); group-3: 42 patients (postcardiotomy CS (PCCS)); group-4: 6 patients (decision/recovery but excluded from analysis). Multivariable logistic regression and Multivariable Coxregression models identified predictors of early -hospital and late mortality, and Odds ratios (ORs) and hazard ratios (HRs) with < 0.
View Article and Find Full Text PDFManagement of Saddle Pulmonary Embolism in the Context of Heparin-Induced Thrombocytopenia and Granulomatosis With Polyangiitis.
Cureus
October 2024
Respiratory Medicine, Glenfield Hospital, University Hospitals of Leicester NHS Trust, Leicester, GBR.
Article Synopsis
- Heparin-induced thrombocytopenia (HIT) is a serious complication from heparin therapy that leads to a low platelet count and increased risk of blood clots.
- A case study involved a 65-year-old woman with a history of granulomatosis with polyangiitis (GPA) and kidney issues, who developed a significant pulmonary embolism.
- The case underscores the complexities of treating pulmonary embolism in patients with HIT, highlighting the importance of tailored anticoagulation approaches and teamwork among healthcare providers.
Heparin-Induced Thrombocytopenia: A Case Report Four Years After the Initiation of Maintenance Hemodialysis.
Cureus
January 2024
General Internal Medicine, Kusumoto Medical Clinic, Fukuoka, JPN.
Heparin-induced thrombocytopenia type II (HIT) is a rare and serious complication of heparin exposure and is always a potential risk in hemodialysis patients who routinely receive heparin. It is particularly likely to occur during the induction phase of dialysis. However, it is known to be less prevalent in long-term maintenance dialysis.
View Article and Find Full Text PDFImmunologic Effects of Heparin Associated With Hemodialysis: Focus on Heparin-Induced Thrombocytopenia.
Semin Nephrol
November 2023
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada; Department of Medicine, McMaster University, Hamilton, Canada; Transfusion Medicine, Hamilton Regional Laboratory Medicine Program, Hamilton General Hospital, Hamilton Health Sciences, Hamilton, Canada; Service of Benign Hematology, Hamilton General Hospital, Hamilton Health Sciences, Hamilton, Canada. Electronic address:
Intermittent hemodialysis (HD) is almost invariably performed with heparin, and thus HD patients are at risk of developing the immune-mediated adverse effect heparin-induced thrombocytopenia (HIT), caused by anti-platelet factor 4/heparin IgG, which strongly activates platelets. HIT patients develop hypercoagulability with greatly increased risk of thrombosis, both venous and arterial. Certain HIT-associated complications are more likely to develop among HD patients, including hemofilter thrombosis despite heparin, intravascular catheter and/or arteriovenous fistula-associated thrombosis, post-heparin bolus anaphylactoid/anaphylactic reactions, and thrombotic stroke and acute limb artery thrombosis (reflecting the high frequency of underlying arteriopathy in many patients with renal failure).
View Article and Find Full Text PDFHeparin-Induced Thrombocytopenia in Chronic Hemodialysis Patients.
Clin Appl Thromb Hemost
June 2023
Internal Medicine Department, Staten Island University Hospital, Staten Island, NY, USA.
Heparin-induced thrombocytopenia (HIT) is a disorder originating from exposure to heparin and has a spectrum of presentation ranging from asymptomatic positive antibodies to thrombotic complications. When symptomatic, it is associated with morbidity and mortality. The incidence of HIT in the ESRD population is yet to be defined.
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